diff --git a/gnu/packages/admin.scm b/gnu/packages/admin.scm
index b1889ceea0..078787061f 100644
--- a/gnu/packages/admin.scm
+++ b/gnu/packages/admin.scm
@@ -5080,10 +5080,17 @@ (define-public jc
                ;; XXX Guix's America/Los_Angeles time zone is somehow broken.
                (add-before 'check 'hack-time-zone
                  (lambda _
-                   (setenv "TZ" "PST8PDT"))))))
-    (native-inputs (list python-pytest))
+                   (setenv "TZ" "PST8PDT")
+                   (substitute* (find-files "tests" "^test.*\\.py$")
+                     (("America/Los_Angeles") "PST8PDT")))))))
+    (native-inputs
+     (list python-pytest
+           python-setuptools
+           python-wheel))
     (propagated-inputs
-     (list python-pygments python-ruamel.yaml python-xmltodict))
+     (list python-pygments
+           python-ruamel.yaml
+           python-xmltodict))
     (home-page "https://github.com/kellyjonbrazil/jc")
     (synopsis "Convert the output of command-line tools to JSON")
     (description "@code{jc} JSONifies the output of many CLI tools and
diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index b80efd85d7..821be215c8 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -2023,8 +2023,13 @@ (define-public python-bcbio-gff
                (base32
                 "1pm1szyxabhn8jismrj9cjhf88ajgcmm39f0cgf36iagw5qakprl"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-biopython python-six))
-    (native-inputs (list python-pytest))
+    (native-inputs
+     (list python-pytest))
+    (propagated-inputs
+     (list python-biopython
+           python-setuptools
+           python-six
+           python-wheel))
     (home-page "https://github.com/chapmanb/bcbb/tree/master/gff")
     (synopsis "Read and write GFF files with Biopython integration")
     (description
@@ -2148,7 +2153,7 @@ (define-public python-bulkvis
                                python-tornado-6
                                python-tqdm
                                python-umap-learn))
-      (native-inputs (list python-pytest))
+      (native-inputs (list python-pytest python-setuptools python-wheel))
       (home-page "https://github.com/LooseLab/bulkVis")
       (synopsis "Interactive visualization of bulk RNA-seq data")
       (description
@@ -2479,7 +2484,11 @@ (define-public python-demuxem
            python-scikit-learn
            python-scipy
            python-seaborn))
-    (native-inputs (list python-cython python-setuptools-scm))
+    (native-inputs
+     (list python-cython
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
     (home-page "https://github.com/lilab-bcb/demuxEM")
     (synopsis "Analyze cell-hashing/nucleus-hashing data")
     (description
@@ -2578,6 +2587,7 @@ (define-public python-hclust2
            python-numpy
            python-pandas
            python-scipy))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/SegataLab/hclust2/")
     (synopsis "Plotting heat-maps for publications")
     (description
@@ -2649,7 +2659,7 @@ (define-public python-htsget
               "111q4pzkav26aa3hkgh948wqlyrq7dq6sjml9z63n3blw8s6b0c4"))))
    (build-system pyproject-build-system)
    (native-inputs
-    (list python-setuptools-scm))
+    (list python-setuptools-scm python-setuptools python-wheel))
    (propagated-inputs
     (list python-humanize python-requests python-six))
    (home-page "https://pypi.org/project/htsget/")
@@ -2749,6 +2759,7 @@ (define-public python-logomaker
     (build-system pyproject-build-system)
     (propagated-inputs
      (list python-matplotlib python-numpy python-pandas))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://logomaker.readthedocs.io")
     (synopsis "Package for making Sequence Logos")
     (description "Logomaker is a Python package for generating
@@ -2983,7 +2994,8 @@ (define-public python-pegasusio
            python-pillow
            python-scipy
            python-zarr))
-    (native-inputs (list python-cython python-setuptools-scm))
+    (native-inputs (list python-cython python-setuptools-scm
+                         python-setuptools python-wheel))
     (home-page "https://github.com/lilab-bcb/pegasusio")
     (synopsis "Read or write single-cell genomics data")
     (description
@@ -3042,7 +3054,7 @@ (define-public python-phenograph
            python-scikit-learn
            python-scipy))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/dpeerlab/PhenoGraph.git")
     (synopsis "Graph-based clustering for high-dimensional single-cell data")
     (description
@@ -3073,6 +3085,7 @@ (define-public python-phylophlan
            python-numpy
            python-pandas
            python-seaborn))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/biobakery/phylophlan")
     (synopsis
      "Phylogenetic analysis of microbial isolates and genomes from metagenomes")
@@ -3152,6 +3165,8 @@ (define (cythonized? c/c++-file)
            python-cython
            kentutils ; for bedGraphToBigWig
            python-six
+           python-setuptools
+           python-wheel
            ;; For the test suite.
            python-pytest
            python-psutil))
@@ -3597,6 +3612,7 @@ (define-public python-readpaf
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false))  ;there are none
     (propagated-inputs (list python-pandas))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/alexomics/read-paf")
     (synopsis "Minimap2 PAF file reader")
     (description
@@ -3778,6 +3794,7 @@ (define-public python-biopython
            (lambda _ (setenv "HOME" "/tmp"))))))
     (propagated-inputs
      (list python-numpy))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://biopython.org/")
     (synopsis "Tools for biological computation in Python")
     (description
@@ -4839,7 +4856,8 @@ (define-public python-bx-python
     (inputs
      (list zlib))
     (native-inputs
-     (list python-cython python-lzo python-pytest))
+     (list python-cython python-lzo python-pytest python-setuptools
+           python-wheel))
     (home-page "https://github.com/bxlab/bx-python")
     (synopsis "Tools for manipulating biological data")
     (description
@@ -5065,6 +5083,8 @@ (define-public python-pysam
     (native-inputs
      (list python-cython
            python-pytest
+           python-setuptools
+           python-wheel
            ;; Dependencies below are are for tests only.
            samtools
            bcftools))
@@ -5158,6 +5178,8 @@ (define-public python-plastid
     (native-inputs
      `(("python-cython" ,python-cython)
        ("python-pytest" ,python-pytest)
+       ("python-setuptools" ,python-setuptools)
+       ("python-wheel" ,python-wheel)
        ("test-data"
         ,(origin
            (method url-fetch)
@@ -5485,7 +5507,8 @@ (define-public python-dnaio
     (arguments
      (list #:tests? #false)) ;there are none
     (native-inputs
-     (list python-cython python-pytest python-setuptools-scm))
+     (list python-cython python-pytest python-setuptools-scm
+           python-setuptools python-wheel))
     (propagated-inputs
      (list python-xopen))
     (home-page "https://github.com/marcelm/dnaio/")
@@ -5837,6 +5860,7 @@ (define-public python-pybigwig
      (list python-numpy))
     (inputs
      (list libbigwig zlib curl))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/dpryan79/pyBigWig")
     (synopsis "Access bigWig files in Python using libBigWig")
     (description
@@ -5962,9 +5986,12 @@ (define-public python-schema-salad
            python-mypy-extensions
            python-rdflib
            python-requests
-           python-ruamel.yaml))
+           python-ruamel.yaml
+           python-setuptools ; For pkg_resources.
+           python-typing-extensions))
     (native-inputs
-     (list python-black python-pytest python-pytest-runner python-pytest-xdist))
+     (list python-black python-pytest python-pytest-runner
+           python-wheel))
     (home-page "https://github.com/common-workflow-language/schema_salad")
     (synopsis "Schema Annotations for Linked Avro Data (SALAD)")
     (description
@@ -6048,6 +6075,7 @@ (define-public python-scrublet
            python-scikit-learn
            python-scipy
            python-umap-learn))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/swolock/scrublet")
     (synopsis "Tool to indentify and remove doublets in single-cell data")
     (description "This package provides a tool for identifying and removing
@@ -6213,6 +6241,7 @@ (define-public cwltool
            python-requests
            python-ruamel.yaml
            python-schema-salad
+           python-setuptools ; For pkg_resources.
            python-shellescape
            python-spython
            python-typing-extensions
@@ -6226,7 +6255,7 @@ (define-public cwltool
            python-pytest-cov
            python-pytest-mock
            python-pytest-runner
-           python-pytest-xdist))
+           python-wheel))
     (home-page
      "https://github.com/common-workflow-language/common-workflow-language")
     (synopsis "Common Workflow Language reference implementation")
@@ -6280,7 +6309,8 @@ (define-public python-dendropy
               (substitute* "tests/test_datamodel_taxon.py"
                 (("collections.Iterable")
                  "collections.abc.Iterable")))))))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-wheel))
+    (propagated-inputs (list python-setuptools))
     (home-page "https://dendropy.org/")
     (synopsis "Library for phylogenetics and phylogenetic computing")
     (description
@@ -7100,7 +7130,8 @@ (define-public python-bamnostic
                (base32
                 "0cjpzyqz6r4lmiwry2gcxdczwpkhl3lyyjg4s8addln17691ysxk"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-pytest))
+    (propagated-inputs (list python-pytest python-setuptools))
+    (native-inputs (list python-wheel))
     (home-page "https://github.com/betteridiot/bamnostic/")
     (synopsis "Tool for binary alignment map, random access and parsing")
     (description
@@ -7198,7 +7229,7 @@ (define-public python-ete3
            python-pyqt
            python-scipy))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "http://etetoolkit.org")
     (synopsis "Python environment for phylogenetic tree exploration")
     (description
@@ -7219,6 +7250,7 @@ (define-public python-illumina-utils
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false))  ;there are none
     (propagated-inputs (list python-matplotlib python-numpy python-levenshtein))
+    (native-inputs (list python-setuptools python-wheel python-pip))
     (home-page "https://github.com/meren/illumina-utils")
     (synopsis "Library and scripts to work with Illumina paired-end data")
     (description
@@ -7242,6 +7274,7 @@ (define-public python-pyani
     (propagated-inputs
      (list python-biopython python-matplotlib python-pandas
            python-scipy python-seaborn))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://widdowquinn.github.io/pyani/")
     (synopsis "Calculate genome-scale average nucleotide identity")
     (description
@@ -10974,7 +11007,9 @@ (define-public python-screed
     (build-system pyproject-build-system)
     (native-inputs
      (list python-pytest-cov
-           python-pytest-runner))
+           python-pytest-runner
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/dib-lab/screed/")
     (synopsis "Short read sequence database utilities")
     (description "Screed parses FASTA and FASTQ files and generates databases.
@@ -11316,7 +11351,7 @@ (define-public seqmagick
     (inputs
      (list python-biopython python-pygtrie))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/fhcrc/seqmagick")
     (synopsis "Tools for converting and modifying sequence files")
     (description
@@ -14553,10 +14588,12 @@ (define-public multiqc
            python-requests
            python-rich
            python-rich-click
+           python-setuptools ; For pkg_resources.
            python-simplejson
            python-spectra))
     (native-inputs
      `(("python-pytest" ,python-pytest)
+       ("python-wheel" ,python-wheel)
        ("tests"
         ,(let ((commit "c3e7400affe3f3ca996973805797af61b93070ba"))
            (origin
@@ -16380,9 +16417,10 @@ (define-public python-goatools
                              python-pydot
                              python-requests
                              python-scipy
+                             python-setuptools
                              python-statsmodels
                              python-xlsxwriter))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-wheel))
     (home-page "https://github.com/tanghaibao/goatools")
     (synopsis "Python scripts to find enrichment of GO terms")
     (description "Python scripts to find enrichment of GO terms.  In addition,
@@ -16498,9 +16536,10 @@ (define-public python-mgatk
            python-pysam
            python-regex
            python-ruamel.yaml
+           python-setuptools
            snakemake))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-wheel))
     (home-page "https://github.com/caleblareau/mgatk")
     (synopsis "Mitochondrial genome analysis toolkit")
     (description "This package is a Python-based command line interface for
@@ -18795,6 +18834,7 @@ (define-public python-scanpy
            python-patsy
            python-scikit-learn
            python-scipy
+           python-setuptools ; For pkg_resources.
            python-seaborn
            python-session-info
            python-sinfo
@@ -19188,7 +19228,9 @@ (define-public python-pyfaidx
            python-mock
            python-numpy
            python-pytest
-           python-pytest-cov))
+           python-pytest-cov
+           python-wheel))
+    (propagated-inputs (list python-setuptools))
     (home-page "http://mattshirley.com")
     (synopsis "Random access to fasta subsequences")
     (description
@@ -19310,7 +19352,7 @@ (define-public python-hicmatrix
            python-scipy
            python-tables))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/deeptools/HiCMatrix/")
     (synopsis "HiCMatrix class for HiCExplorer and pyGenomeTracks")
     (description
@@ -20173,6 +20215,7 @@ (define-public cnvkit
            ;; R packages
            r-dnacopy))
     (inputs (list r-minimal)) ;for tests
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://cnvkit.readthedocs.org/")
     (synopsis "Copy number variant detection from targeted DNA sequencing")
     (description
@@ -22474,7 +22517,9 @@ (define-public python-cgatcore
      (list python-pytest
            lsof
            inetutils
-           openssl))
+           openssl
+           python-setuptools
+           python-wheel))
     (inputs (list time))
     (propagated-inputs
      (list python-apsw
@@ -22979,6 +23024,7 @@ (define-public python-dna-features-viewer
      (list python-biopython
            python-matplotlib
            python-packaging))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page
      "https://github.com/Edinburgh-Genome-Foundry/DnaFeaturesViewer")
     (synopsis "Plot features from DNA sequences")
diff --git a/gnu/packages/bootloaders.scm b/gnu/packages/bootloaders.scm
index 788c7dc9ef..0e27113155 100644
--- a/gnu/packages/bootloaders.scm
+++ b/gnu/packages/bootloaders.scm
@@ -76,6 +76,7 @@ (define-module (gnu packages bootloaders)
   #:use-module (gnu packages version-control)
   #:use-module (gnu packages virtualization)
   #:use-module (gnu packages xorg)
+  #:use-module (gnu packages python-build)
   #:use-module (gnu packages python-web)
   #:use-module (gnu packages python-xyz)
   #:use-module (guix build-system gnu)
@@ -787,6 +788,8 @@ (define u-boot
            pkg-config                   ;for 'make menuconfig'
            python
            python-pyelftools
+           python-setuptools
+           python-wheel
            swig
            (list util-linux "lib")))
     (home-page "https://www.denx.de/wiki/U-Boot/")
diff --git a/gnu/packages/check.scm b/gnu/packages/check.scm
index 41ea34249b..a8276d16b1 100644
--- a/gnu/packages/check.scm
+++ b/gnu/packages/check.scm
@@ -1041,7 +1041,7 @@ (define-public python-gixy
                  (base32
                   "0gymjcnvjx9snyrzdbmjnk93ibb161q72xam29vnl3yyac4r1330"))))
       (build-system pyproject-build-system)
-      (native-inputs (list python-nose))
+      (native-inputs (list python-nose python-setuptools python-wheel))
       (propagated-inputs
        (list python-cached-property python-configargparse
              python-jinja2 python-six
@@ -2174,7 +2174,8 @@ (define-public python-pytest-forked
      ;; 'hypothesis' plugin is not in the environment (due to
      ;; <http://issues.guix.gnu.org/25235>), which would cause the test suite
      ;; to fail (see: https://github.com/pytest-dev/pytest-forked/issues/54).
-     (list python-pytest-bootstrap python-setuptools-scm))
+     (list python-pytest-bootstrap python-setuptools
+           python-setuptools-scm python-wheel))
     (home-page "https://github.com/pytest-dev/pytest-forked")
     (synopsis "Pytest plugin to run tests in isolated forked subprocesses")
     (description "This package provides a Pytest plugin which enables running
@@ -2499,7 +2500,7 @@ (define-public python-pytest-asyncio
                  (lambda _
                    (setenv "SETUPTOOLS_SCM_PRETEND_VERSION"
                            #$(package-version this-package)))))))
-    (native-inputs (list python-setuptools-scm))
+    (native-inputs (list python-setuptools-scm python-setuptools python-wheel))
     (propagated-inputs (list python-pytest))
     (home-page "https://github.com/pytest-dev/pytest-asyncio")
     (synopsis "Pytest support for asyncio")
@@ -2992,7 +2993,9 @@ (define-public python-pytest-mypy-plugins
                              python-mypy
                              python-pytest
                              python-pyyaml
+                             python-setuptools
                              python-regex))
+    (native-inputs (list python-wheel))
     (home-page "https://github.com/TypedDjango/pytest-mypy-plugins")
     (synopsis "Pytest plugin for writing tests for mypy plugins")
     (description "This package provides a pytest plugin for writing tests for
diff --git a/gnu/packages/databases.scm b/gnu/packages/databases.scm
index dcd122cb22..b68f695513 100644
--- a/gnu/packages/databases.scm
+++ b/gnu/packages/databases.scm
@@ -3229,6 +3229,7 @@ (define-public python-aiomysql
     (build-system pyproject-build-system)
     (arguments '(#:tests? #f))           ;test suite requires docker
     (propagated-inputs (list python-pymysql))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/aio-libs/aiomysql")
     (synopsis "MySQL driver for Python")
     (description "@code{aiomysql} is a driver for accessing a MySQL database
@@ -3670,7 +3671,8 @@ (define-public python-sqlalchemy
     (build-system pyproject-build-system)
     (native-inputs
      (list python-cython ; for C extensions
-           python-pytest python-mock python-pytest-xdist)) ; for tests
+           python-pytest python-mock python-pytest-xdist ; for tests
+           python-setuptools python-wheel))
     (propagated-inputs
      (list python-greenlet))
     (arguments
@@ -3905,7 +3907,7 @@ (define-public python-sqlite-utils
     (propagated-inputs (list python-click python-click-default-group
                              python-dateutil python-sqlite-fts4
                              python-tabulate))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/simonw/sqlite-utils")
     (synopsis
      "CLI tool and Python utility functions for manipulating SQLite databases")
@@ -3978,7 +3980,7 @@ (define-public python-apsw
          "10yfbasi4mq63g0svyl1h49ylwn9znjylq78id16dzxzk9q9ipdx"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list unzip))
+     (list unzip python-setuptools python-wheel))
     (inputs (list sqlite-next))         ;SQLite 3.45.1 required.
     (arguments
      (list
@@ -4333,7 +4335,7 @@ (define-public python-hiredis
                             ;; The fix was forwarded upstream, see:
                             ;; https://github.com/redis/hiredis-py/pull/160.
                             (delete-file "tests/__init__.py"))))))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (inputs (list hiredis))
     (home-page "https://github.com/redis/hiredis-py")
     (synopsis "Python extension that wraps protocol parsing code in hiredis")
@@ -4457,6 +4459,8 @@ (define-public python-redis
            python-pytest
            python-pytest-asyncio
            python-pytest-timeout
+           python-setuptools
+           python-wheel
            redis))
     (propagated-inputs
      (list python-async-timeout))
diff --git a/gnu/packages/digest.scm b/gnu/packages/digest.scm
index ae3bf8da75..8e91a9532a 100644
--- a/gnu/packages/digest.scm
+++ b/gnu/packages/digest.scm
@@ -116,7 +116,10 @@ (define-public python-xxhash
          "1hdxcscry59gh0znlm71ya23mm9rfmvz8lvvlplzxzf63pib28dc"))))
     (build-system pyproject-build-system)
     ;; Needed to embed the correct version string
-    (native-inputs (list python-setuptools-scm))
+    (native-inputs
+     (list python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/ifduyue/python-xxhash")
     (synopsis "Python binding for xxHash")
     (description "This package provides Python bindings for the xxHash hash
diff --git a/gnu/packages/engineering.scm b/gnu/packages/engineering.scm
index a67d83e57b..c829ece846 100644
--- a/gnu/packages/engineering.scm
+++ b/gnu/packages/engineering.scm
@@ -2669,9 +2669,14 @@ (define-public python-pyvisa
                             (substitute* "pyvisa/shell.py"
                               (("from .thirdparty import prettytable")
                                "import prettytable")))))))
-    (native-inputs (list python-pytest))
-    (propagated-inputs (list python-dataclasses python-prettytable
-                             python-typing-extensions))
+    (native-inputs
+     (list python-pytest
+           python-setuptools
+           python-wheel))
+    (propagated-inputs
+     (list python-dataclasses
+           python-prettytable
+           python-typing-extensions))
     (home-page "https://pyvisa.readthedocs.io/en/latest/")
     (synopsis "Python binding for the VISA library")
     (description "PyVISA is a Python package for support of the
diff --git a/gnu/packages/fontutils.scm b/gnu/packages/fontutils.scm
index 614d62f439..c7443fe1a1 100644
--- a/gnu/packages/fontutils.scm
+++ b/gnu/packages/fontutils.scm
@@ -532,7 +532,11 @@ (define-public python-ufo2ft
        (sha256
         (base32 "1rg2997af8blvswlwif0kpz2vxrlh555gzqslz6yv9y7i7v8lphl"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest python-setuptools-scm))
+    (native-inputs
+     (list python-pytest
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (propagated-inputs
      (list python-booleanoperations
            python-cffsubr
@@ -679,7 +683,8 @@ (define-public python-glyphslib
                        "--ignore=tests/builder/interpolation_test.py")))
     (native-inputs
      (list python-setuptools-scm
-
+           python-setuptools
+           python-wheel
            ;; For tests.
            python-pytest
            python-xmldiff))
@@ -859,6 +864,7 @@ (define-public psautohint
            python-pytest-cov
            python-pytest-xdist
            python-setuptools-scm
+           python-setuptools
            python-wheel))
     (home-page "https://github.com/adobe-type-tools/psautohint")
     (synopsis "Adobe's PostScript autohinter")
@@ -1782,8 +1788,13 @@ (define-public python-ufolib2
         (base32 "0yx4i8q5rfyqhr2fj70a7z1bp1jv7bdlr64ww9z4nv9ycbda4x9j"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest python-setuptools-scm))
-    (propagated-inputs (list python-attrs python-fonttools))
+     (list python-pytest
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
+    (propagated-inputs
+     (list python-attrs
+           python-fonttools))
     (home-page "https://github.com/fonttools/ufoLib2")
     (synopsis "Unified Font Object (UFO) font processing library")
     (description "The ufoLib2 Python library is meant to be a thin
diff --git a/gnu/packages/geo.scm b/gnu/packages/geo.scm
index a9a9e1c945..50decdd14a 100644
--- a/gnu/packages/geo.scm
+++ b/gnu/packages/geo.scm
@@ -359,7 +359,9 @@ (define-public python-h3
            python-numpy
            python-pytest
            python-scikit-build
-           python-setuptools-scm))
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
     (inputs (list h3))
     (home-page "https://uber.github.io/h3-py")
     (synopsis "Python bindings for H3")
@@ -1012,7 +1014,7 @@ (define-public python-geopandas
       (list python-fiona python-packaging python-pandas python-pyproj
             python-shapely))
     (native-inputs
-      (list python-pytest))
+      (list python-pytest python-setuptools python-wheel))
     (home-page "https://geopandas.org")
     (synopsis "Geographic pandas extensions")
     (description "The goal of GeoPandas is to make working with
@@ -1141,7 +1143,7 @@ (define-public python-osmnx
                              python-pandas
                              python-requests
                              python-shapely))
-    (native-inputs (list python-hatchling python-pytest))
+    (native-inputs (list python-hatchling python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/gboeing/osmnx")
     (synopsis
      "Retrieve, model, analyze, and visualize OpenStreetMap street networks")
@@ -2109,7 +2111,7 @@ (define-public python-rtree
                   (string-append  "\"" libspatialindex
                                   "/lib/libspatialindex_c.so\"")))))))))
     (native-inputs
-     (list python-numpy python-pytest python-wheel))
+     (list python-numpy python-pytest python-setuptools python-wheel))
     (inputs
      (list libspatialindex))
     (home-page "https://github.com/Toblerity/rtree")
diff --git a/gnu/packages/graph.scm b/gnu/packages/graph.scm
index 02033c25b3..46e556ecc0 100644
--- a/gnu/packages/graph.scm
+++ b/gnu/packages/graph.scm
@@ -250,8 +250,12 @@ (define-public python-igraph
                       var (format #f "[~s]~%"
                                   (string-append igraph "/lib")))))))))))
       (inputs (list igraph))
-      (propagated-inputs (list python-texttable))
-      (native-inputs (list python-pytest))
+      (propagated-inputs
+       (list python-texttable))
+      (native-inputs
+       (list python-pytest
+             python-setuptools
+             python-wheel))
       (home-page "https://igraph.org/python/")
       (synopsis "Python bindings for the igraph network analysis library"))))
 
@@ -419,11 +423,12 @@ (define-public python-vtraag-louvain
                (("self.use_pkgconfig = False")
                 "self.use_pkgconfig = True")))))))
     (inputs (list igraph))
-    (propagated-inputs (list python-igraph))
+    (propagated-inputs (list python-igraph python-setuptools))
     (native-inputs
      (list pkg-config
            python-ddt
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-wheel))
     (home-page "https://github.com/vtraag/louvain")
     (synopsis "Community detection in large networks")
     (description
diff --git a/gnu/packages/graphviz.scm b/gnu/packages/graphviz.scm
index a1626d3c58..b438c86b5c 100644
--- a/gnu/packages/graphviz.scm
+++ b/gnu/packages/graphviz.scm
@@ -160,7 +160,9 @@ (define-public python-graphviz
            python-mock
            python-pytest
            python-pytest-cov
-           python-pytest-mock))
+           python-pytest-mock
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/xflr6/graphviz")
     (synopsis "Simple Python interface for Graphviz")
     (description
diff --git a/gnu/packages/license.scm b/gnu/packages/license.scm
index b2216615b9..53a0b98f9a 100644
--- a/gnu/packages/license.scm
+++ b/gnu/packages/license.scm
@@ -191,12 +191,17 @@ (define-public reuse
                         (add-before 'check 'chdir
                           (lambda _
                             (chdir "/tmp"))))))
-    (native-inputs (list python-poetry-core python-pytest))
-    (inputs (list python-binaryornot
-                  python-boolean.py
-                  python-debian
-                  python-jinja2
-                  python-license-expression))
+    (native-inputs
+     (list python-poetry-core
+           python-pytest
+           python-wheel))
+    (inputs
+     (list python-binaryornot
+           python-boolean.py
+           python-debian
+           python-jinja2
+           python-license-expression
+           python-setuptools)) ; For pkg_resources.
     (home-page "https://reuse.software/")
     (synopsis "Provide and verify copyright and licensing information")
     (description
diff --git a/gnu/packages/machine-learning.scm b/gnu/packages/machine-learning.scm
index a55d412a1e..9d76e719ed 100644
--- a/gnu/packages/machine-learning.scm
+++ b/gnu/packages/machine-learning.scm
@@ -1047,7 +1047,7 @@ (define-public python-sacrebleu
                              python-portalocker
                              python-regex
                              python-tabulate))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/mjpost/sacrebleu")
     (synopsis
      "Compute shareable, comparable, and reproducible BLEU, chrF, and TER scores")
@@ -1088,7 +1088,7 @@ (define-public python-spacy-legacy
     (build-system pyproject-build-system)
     ;; This package depends on spacy, which depends on this package.
     (arguments (list #:tests? #false))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://spacy.io")
     (synopsis "Legacy registered functions for spaCy backwards compatibility")
     (description
@@ -1109,7 +1109,7 @@ (define-public python-spacy-loggers
     (build-system pyproject-build-system)
     ;; This package depends on spacy, which depends on this package.
     (arguments (list #:tests? #false))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/explosion/spacy-loggers")
     (synopsis "Logging utilities for SpaCy")
     (description "This package provides logging utilities for the SpaCy
@@ -1967,6 +1967,8 @@ (define-public python-imbalanced-learn
                          python-pandas
                          python-pytest
                          python-pytest-cov
+                         python-setuptools
+                         python-wheel
                          tensorflow))
     (home-page "https://github.com/scikit-learn-contrib/imbalanced-learn")
     (synopsis "Toolbox for imbalanced dataset in machine learning")
@@ -2147,7 +2149,9 @@ (define-public python-cleanlab
      (list python-pytest
            python-pytest-lazy-fixture
            python-pytorch
-           python-torchvision))
+           python-torchvision
+           python-setuptools
+           python-wheel))
     (home-page "https://cleanlab.ai")
     (synopsis "Automatically find and fix dataset issues")
     (description
@@ -2179,7 +2183,7 @@ (define-public python-cleanlab-1
            python-scipy
            python-tqdm))
     (native-inputs
-     (list python-pytest))))
+     (list python-pytest python-setuptools python-wheel))))
 
 (define-public python-cma
   (package
@@ -2220,7 +2224,7 @@ (define-public python-cmaes
         (base32 "17bk60mhkglz6s7wz6xcyhw1h4mvghc1iid0805dra7jdyafwrfn"))
        (file-name (git-file-name name version))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-hypothesis))
+    (native-inputs (list python-hypothesis python-setuptools python-wheel))
     (propagated-inputs (list python-numpy))
     (home-page "https://github.com/CyberAgentAILab/cmaes")
     (synopsis "CMA-ES implementation for Python")
@@ -2386,13 +2390,15 @@ (define-public python-hyperopt
            python-networkx
            python-numpy
            python-scipy
+           python-setuptools ; For pkg_resources.
            python-six
            python-tqdm))
     (native-inputs
      (list python-black
            python-nose
            python-pymongo
-           python-pytest))
+           python-pytest
+           python-wheel))
     (home-page "https://hyperopt.github.io/hyperopt/")
     (synopsis "Library for hyperparameter optimization")
     (description "Hyperopt is a Python library for serial and parallel
@@ -3962,7 +3968,8 @@ (define-public python-tensorly
          ;; nor is examples/plot_quantum.py
          " and not test_file_is_generated"))))
     (propagated-inputs (list python-jsmin python-numpy python-scipy))
-    (native-inputs (list python-pytest python-pytest-cov python-sphinx))
+    (native-inputs (list python-pytest python-pytest-cov python-sphinx
+                         python-setuptools python-wheel))
     (home-page "https://github.com/tensorly/tensorly")
     (synopsis "Tensor learning in Python")
     (description
@@ -5123,6 +5130,7 @@ (define-public python-readchar
            (lambda _
              (delete-file "readchar/_win_read.py"))))))
     (propagated-inputs (list python-setuptools))
+    (native-inputs (list python-wheel))
     (home-page "https://github.com/magmax/python-readchar")
     (synopsis "Library to easily read single chars and key strokes")
     (description "This package provides a Python library to easily read single
@@ -5391,7 +5399,7 @@ (define-public python-torchvision
            python-pillow-simd
            python-pytorch))
     (native-inputs
-     (list which python-pytest))
+     (list which python-pytest python-setuptools python-wheel))
     (home-page "https://pytorch.org/vision/stable/index.html")
     (synopsis "Datasets, transforms and models specific to computer vision")
     (description
@@ -5994,7 +6002,7 @@ (define-public python-brian2
                              ;; Required by codegen.
                              python-setuptools
                              python-sympy))
-    (native-inputs (list python-pytest python-pytest-xdist))
+    (native-inputs (list python-pytest python-pytest-xdist python-wheel))
     (home-page "https://briansimulator.org/")
     (synopsis "Clock-driven simulator for spiking neural networks")
     (description
diff --git a/gnu/packages/monitoring.scm b/gnu/packages/monitoring.scm
index 6325c9b96f..d6fab3f32c 100644
--- a/gnu/packages/monitoring.scm
+++ b/gnu/packages/monitoring.scm
@@ -326,7 +326,10 @@ (define-public zabbix-cli
                                      (string-append #$output "/share/doc/"
                                                     #$name "/html")))))))
     (native-inputs
-     (list python-pytest python-sphinx))
+     (list python-pytest
+           python-setuptools
+           python-sphinx
+           python-wheel))
     (inputs
      (list ncurses python-requests))
     (home-page "https://github.com/unioslo/zabbix-cli")
diff --git a/gnu/packages/package-management.scm b/gnu/packages/package-management.scm
index 8b4c408874..97c0bb675d 100644
--- a/gnu/packages/package-management.scm
+++ b/gnu/packages/package-management.scm
@@ -1090,7 +1090,11 @@ (define-public python-anaconda-client
          (add-before 'check 'set-HOME
            (lambda _ (setenv "HOME" "/tmp"))))))
     (propagated-inputs
-     (list python-clyent python-nbformat python-pyyaml python-requests))
+     (list python-clyent
+           python-nbformat
+           python-pyyaml
+           python-requests
+           python-setuptools))
     (native-inputs
      (list python-coverage
            python-dateutil
@@ -1098,7 +1102,8 @@ (define-public python-anaconda-client
            python-mock
            python-pillow
            python-pytest
-           python-pytz))
+           python-pytz
+           python-wheel))
     (home-page "https://github.com/Anaconda-Platform/anaconda-client")
     (synopsis "Anaconda Cloud command line client library")
     (description
diff --git a/gnu/packages/potassco.scm b/gnu/packages/potassco.scm
index c5d00c9b1c..e08b478c22 100644
--- a/gnu/packages/potassco.scm
+++ b/gnu/packages/potassco.scm
@@ -589,7 +589,7 @@ (define-public python-clorm
                    (setenv "CLORM_NOCLINGO" "1")
                    (delete-file "tests/test_mypy_query.py"))))))
     (propagated-inputs (list python-clingo))
-    (native-inputs (list python-typing-extensions))
+    (native-inputs (list python-typing-extensions python-setuptools python-wheel))
     (home-page "https://potassco.org")
     (synopsis "Object relational mapping to clingo")
     (description "@acronym{Clorm, Clingo ORM} provides an @acronym{ORM,
@@ -651,6 +651,7 @@ (define-public python-telingo
                 "1q6hlh4b5hsa4n5agvmfa9rhsxfd2g6kpl4b9kfccwbmf6dh51k6"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-clingo))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://potassco.org/")
     (synopsis "Solve dynamic temporal logic programs")
     (description "This package provides a system to solve dynamic temporal
@@ -678,8 +679,10 @@ (define-public python-clingraph
                              python-imageio
                              python-jinja2
                              python-jsonschema
-                             python-networkx))
-    (native-inputs (list dot2tex graphviz python-pylint python-pytest))
+                             python-networkx
+                             python-setuptools))
+    (native-inputs (list dot2tex graphviz python-pylint python-pytest
+                         python-wheel))
     (home-page "https://github.com/potassco/clingraph")
     (synopsis "Visualizer for graphs defined as logic programs")
     (description
diff --git a/gnu/packages/protobuf.scm b/gnu/packages/protobuf.scm
index 59f49c8cf4..11e81527e0 100644
--- a/gnu/packages/protobuf.scm
+++ b/gnu/packages/protobuf.scm
@@ -395,7 +395,9 @@ (define-public python-mypy-protobuf
      (list python-grpc-stubs
            python-grpcio-tools
            python-pytest
-           python-typing-extensions))
+           python-typing-extensions
+           python-setuptools
+           python-wheel))
     (propagated-inputs
      (list protobuf
            python-protobuf
diff --git a/gnu/packages/python-build.scm b/gnu/packages/python-build.scm
index 47c9c5a9ff..d236822007 100644
--- a/gnu/packages/python-build.scm
+++ b/gnu/packages/python-build.scm
@@ -219,7 +219,7 @@ (define-public python-trove-classifiers
     (build-system pyproject-build-system)
     (arguments (list #:build-backend "setuptools.build_meta"
                      #:tests? #f))      ;keep dependencies to a minimum
-    (native-inputs (list python-wheel))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/pypa/trove-classifiers")
     (synopsis "Canonical source for classifiers on PyPI")
     (description "This package is the canonical source for classifiers use on
@@ -650,6 +650,7 @@ (define-public python-flit-scm
                      ;; builder instead.
                      #:build-backend "setuptools.build_meta"))
     (propagated-inputs (list python-flit-core python-setuptools-scm python-tomli))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://gitlab.com/WillDaSilva/flit_scm")
     (synopsis "PEP 518 build backend combining flit_core and setuptools_scm")
     (description "This package provides a PEP 518 build backend that uses
diff --git a/gnu/packages/python-check.scm b/gnu/packages/python-check.scm
index 8599d8bf1d..3d8fe98bd4 100644
--- a/gnu/packages/python-check.scm
+++ b/gnu/packages/python-check.scm
@@ -792,8 +792,13 @@ (define-public python-pytest-doctestplus
                          ;; Requiring git available.
                          " and not test_generate_diff_basic"))))
     (native-inputs
-     (list python-numpy python-pytest python-setuptools-scm))
-    (home-page "https://github.com/scientific-python/pytest-doctestplus")
+     (list python-numpy
+           python-pytest
+           python-setuptools-scm
+           python-wheel))
+    (propagated-inputs
+     (list python-setuptools)) ;for pkg_resources
+    (home-page "https://github.com/astropy/pytest-doctestplus")
     (synopsis "Pytest plugin with advanced doctest features")
     (description
      "This package contains a plugin for the Pytest framework that provides
@@ -842,7 +847,9 @@ (define-public python-pytest-filter-subpackage
      (list python-pytest
            python-pytest-cov
            python-pytest-doctestplus
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/astropy/pytest-filter-subpackage")
     (synopsis "Pytest plugin for filtering based on sub-packages")
     (description
@@ -947,7 +954,10 @@ (define-public python-pytest-remotedata
                                  "not test_default_behavior"
                                  " and not test_strict_with_decorator"))))
     (native-inputs
-     (list python-pytest python-setuptools-scm))
+     (list python-pytest
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
     (propagated-inputs
      (list python-packaging))
     (home-page "https://github.com/astropy/pytest-remotedata")
@@ -1042,6 +1052,7 @@ (define-public python-pytest-mpl
       #:test-flags #~(list "-m" "mpl_image_compare")))
     (native-inputs
      (list python-pytest
+           python-setuptools
            python-setuptools-scm
            python-wheel))
     (propagated-inputs
@@ -2075,7 +2086,11 @@ (define-public python-memory-profiler
                 (("def test_memory_profiler")
                  "def __off_test_memory_profiler")))))))
     (native-inputs
-     (list python-pytest python-pytest-fixture-config python-safety))
+     (list python-pytest
+           python-pytest-fixture-config
+           python-safety
+           python-setuptools
+           python-wheel))
     (propagated-inputs (list python-psutil))
     (home-page "https://github.com/pythonprofilers/memory_profiler")
     (synopsis "Memory profiler for Python")
@@ -2532,7 +2547,7 @@ (define-public python-aioresponses
     (native-inputs
      (list python-pbr python-ddt python-pytest))
     (propagated-inputs
-     (list python-aiohttp))
+     (list python-aiohttp python-setuptools))
     (home-page "https://github.com/pnuckowski/aioresponses")
     (synopsis "Mock out requests made by ClientSession from aiohttp package")
     (description
@@ -2780,7 +2795,9 @@ (define-public python-nox
     (native-inputs
      (list python-jinja2
            python-pytest
-           python-tox))
+           python-tox
+           python-setuptools
+           python-wheel))
     (home-page "https://nox.thea.codes/")
     (synopsis "Flexible test automation")
     (description
@@ -2933,8 +2950,12 @@ (define-public python-pytest-httpx
        (sha256
         (base32 "1ncpd74hmsz4sadvjg99fnfscxpgh3mc2siini0dhxzwgwdkk5i7"))))
     (build-system pyproject-build-system)
+    (native-inputs
+     (list python-pytest
+           python-pytest-asyncio
+           python-setuptools
+           python-wheel))
     (propagated-inputs (list python-httpx))
-    (native-inputs (list python-pytest python-pytest-asyncio))
     (home-page "https://colin-b.github.io/pytest_httpx/")
     (synopsis "Pytest plugin to mock httpx")
     (description "This package provides a pytest fixture to mock httpx
@@ -3011,7 +3032,11 @@ (define-public python-vulture
                                       ;; skip test that uses python-pint
                                       ;; pint has many dependencies
                                       "not test_whitelists_with_python")))))))
-    (native-inputs (list python-pytest python-pytest-cov))
+    (native-inputs
+     (list python-pytest
+           python-pytest-cov
+           python-setuptools
+           python-wheel))
     (propagated-inputs (list python-toml))
     (home-page "https://github.com/jendrikseipp/vulture")
     (synopsis "Find dead Python code")
diff --git a/gnu/packages/python-compression.scm b/gnu/packages/python-compression.scm
index 5a6383facc..3c15b1b682 100644
--- a/gnu/packages/python-compression.scm
+++ b/gnu/packages/python-compression.scm
@@ -114,7 +114,9 @@ (define-public python-multivolumefile
            python-hypothesis
            python-pyannotate
            python-pytest
-           python-pytest-cov))
+           python-pytest-cov
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/miurahr/multivolume")
     (synopsis "Treat multiple files as one")
     (description "MultiVolumefile is a Python library that provides a
@@ -251,7 +253,9 @@ (define-public python-pybcj
            python-hypothesis
            python-pytest
            python-pytest-cov
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://codeberg.org/miurahr/pybcj")
     (synopsis "BCJ filter library")
     (description "In data compression, BCJ, short for Branch-Call-Jump, refers
@@ -311,6 +315,7 @@ (define-public python-brotlicffi
                (setenv "USE_SHARED_BROTLI" "1"))))))
     (propagated-inputs (list python-cffi))
     (inputs (list brotli))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/python-hyper/brotlicffi")
     (synopsis "Python CFFI bindings to the Brotli library")
     (description "This package provides Python CFFI bindings to the Brotli
@@ -332,7 +337,9 @@ (define-public python-inflate64
     (native-inputs
      (list python-pyannotate
            python-pytest
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://pypi.org/project/inflate64/")
     (synopsis "Compression/decompression library")
     (description "The @code{inflate64} package provides @code{Deflater} and
@@ -361,7 +368,7 @@ (define-public python-isal
          (add-after 'unpack 'use-dynamic-linking
            (lambda _ (setenv "PYTHON_ISAL_LINK_DYNAMIC" "1"))))))
     (inputs (list isa-l))
-    (native-inputs (list python-cython))
+    (native-inputs (list python-cython python-setuptools python-wheel))
     (home-page "https://github.com/pycompression/python-isal")
     (synopsis "Python bindings for the ISA-L compression library")
     (description
@@ -407,7 +414,9 @@ (define-public python-pyppmd
            python-pytest-benchmark
            python-pytest-cov
            python-pytest-timeout
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/miurahr/pyppmd")
     (synopsis "PPMd compression/decompression library")
     (description "Pyppmd provides classes and functions for compressing and
@@ -468,9 +477,8 @@ (define-public python-py7zr
            python-pyzstd
            python-texttable))
     (native-inputs
-     (list python-setuptools
-           python-setuptools-scm
-           python-coverage
+     (list python-coverage
+           python-setuptools
            python-coveralls
            python-libarchive-c
            python-py-cpuinfo
@@ -479,7 +487,9 @@ (define-public python-py7zr
            python-pytest-benchmark
            python-pytest-cov
            python-pytest-remotedata
-           python-pytest-timeout))
+           python-pytest-timeout
+           python-setuptools-scm
+           python-wheel))
     (home-page "https://github.com/miurahr/py7zr")
     (synopsis "7-zip in Python")
     (description "This package provides py7zr, which implements 7-zip
diff --git a/gnu/packages/python-crypto.scm b/gnu/packages/python-crypto.scm
index 19df7ef3a9..99c7eb5881 100644
--- a/gnu/packages/python-crypto.scm
+++ b/gnu/packages/python-crypto.scm
@@ -302,7 +302,9 @@ (define-public python-keyring
     (native-inputs
      (list python-toml
            python-pytest
-           python-setuptools-scm))
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
     (propagated-inputs
      (list python-importlib-metadata
            python-jaraco-classes
@@ -530,11 +532,13 @@ (define-public python-cryptography-vectors
     (build-system pyproject-build-system)
     (arguments (list #:tests? #f))  ; No tests included.
     (native-inputs
-     (list python-flit-core))
+     (list python-flit-core
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/pyca/cryptography")
     (synopsis "Test vectors for the cryptography package")
     (description
-      "This package contains test vectors for the cryptography package.")
+     "This package contains test vectors for the cryptography package.")
     ;; Distributed under either BSD-3 or ASL2.0
     (license (list license:bsd-3 license:asl2.0))))
 
@@ -574,7 +578,10 @@ (define-public python-cryptography
            python-iso8601
            python-pretend
            python-pytest                ;for subtests
-           python-pytest-benchmark))
+           python-pytest-benchmark
+           python-pytest-subtests
+           python-setuptools
+           python-wheel))
     (inputs (list python-cryptography-rust))
     (propagated-inputs (list python-cffi))
     (home-page "https://github.com/pyca/cryptography")
@@ -1093,7 +1100,7 @@ (define-public python-m2crypto
        ;; certificates.
        #:tests? #f))
     (inputs (list openssl))
-    (native-inputs (list swig))
+    (native-inputs (list swig python-setuptools python-wheel))
     (home-page "https://gitlab.com/m2crypto/m2crypto")
     (synopsis "Python crypto and TLS toolkit")
     (description "@code{M2Crypto} is a complete Python wrapper for OpenSSL
@@ -1280,7 +1287,11 @@ (define-public python-service-identity
                (base32
                 "0d4x84crbz0a17d8gi90z6zlxwm9pslc65rx0cdw2797ra360v3f"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-idna python-pytest))
+    (native-inputs
+     (list python-idna
+           python-pytest
+           python-setuptools
+           python-wheel))
     (propagated-inputs (list python-attrs python-cryptography python-pyasn1
                              python-pyasn1-modules python-six))
     (home-page "https://service-identity.readthedocs.io/")
@@ -1511,6 +1522,8 @@ (define-public python-trustme
            python-pytest
            python-pytest-cov
            python-service-identity
+           python-setuptools
+           python-wheel
            python-zipp))
     (propagated-inputs
      (list python-cryptography
diff --git a/gnu/packages/python-science.scm b/gnu/packages/python-science.scm
index cd2434c39f..58d00966e3 100644
--- a/gnu/packages/python-science.scm
+++ b/gnu/packages/python-science.scm
@@ -370,9 +370,12 @@ (define-public python-scikit-allel
              (invoke "python" "setup.py" "build_ext" "--inplace"))))))
     (propagated-inputs
      (list python-dask
-           python-numpy))
+           python-numpy
+           python-click))
     (native-inputs
      (list python-cython
+           python-setuptools
+           python-wheel
            ;; The following are all needed for the tests
            htslib
            python-h5py
@@ -591,7 +594,7 @@ (define-public python-scikit-optimize
            python-scikit-learn
            python-scipy))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://scikit-optimize.github.io/")
     (synopsis "Sequential model-based optimization toolbox")
     (description "Scikit-Optimize, or @code{skopt}, is a simple and efficient
@@ -1852,7 +1855,7 @@ (define-public python-xarray
              (string-append "not test_datetime_conversion_warning"
                             " and not test_timedelta_conversion_warning"))))
     (native-inputs
-     (list python-setuptools-scm python-pytest))
+     (list python-setuptools python-setuptools-scm python-pytest python-wheel))
     (propagated-inputs
      (list python-numpy python-packaging python-pandas))
     (home-page "https://github.com/pydata/xarray")
@@ -2019,7 +2022,9 @@ (define-public python-pytensor
     (native-inputs (list python-cython
                          python-pytest
                          python-pytest-mock
-                         python-versioneer))
+                         python-versioneer
+                         python-setuptools
+                         python-wheel))
     (propagated-inputs (list python-cons
                              python-etuples
                              python-filelock
@@ -2882,7 +2887,9 @@ (define-public python-plotnine
                          python-pandas
                          python-pytest
                          python-pytest-cov
+                         python-setuptools
                          python-setuptools-scm
+                         python-wheel
                          tzdata-for-tests))
     (home-page "https://github.com/has2k1/plotnine")
     (synopsis "Grammar of Graphics for Python")
@@ -3666,7 +3673,12 @@ (define-public python-libneuroml
                 "0mrm4rd6x1sm6hkvhk20mkqp9q53sl3lbvq6hqzyymkw1iqq6bhy"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-lxml python-six))
-    (native-inputs (list python-pytest python-numpy python-tables))
+    (native-inputs
+     (list python-pytest
+           python-numpy
+           python-setuptools
+           python-tables
+           python-wheel))
     (home-page "https://libneuroml.readthedocs.org/en/latest/")
     (synopsis
      "Python library for working with NeuroML descriptions of neuronal models")
diff --git a/gnu/packages/python-web.scm b/gnu/packages/python-web.scm
index 0d023fe58d..3be51c3299 100644
--- a/gnu/packages/python-web.scm
+++ b/gnu/packages/python-web.scm
@@ -444,7 +444,12 @@ (define-public python-aiosignal
     (build-system pyproject-build-system)
     (arguments (list #:test-flags #~(list "tests")))
     (propagated-inputs (list python-frozenlist))
-    (native-inputs (list python-pytest python-pytest-asyncio python-pytest-cov))
+    (native-inputs
+     (list python-pytest
+           python-pytest-asyncio
+           python-pytest-cov
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/aio-libs/aiosignal")
     (synopsis "Callback manager for Python @code{asyncio} projects")
     (description "This Python module provides @code{Signal}, an abstraction to
@@ -765,7 +770,9 @@ (define-public python-asgi-csrf
                          python-httpx
                          python-pytest
                          python-pytest-asyncio
-                         python-starlette))
+                         python-starlette
+                         python-setuptools
+                         python-wheel))
     (home-page "https://github.com/simonw/asgi-csrf")
     (synopsis "ASGI middleware for protecting against CSRF attacks")
     (description "This Asynchronous Server Gateway Interface (ASGI)
@@ -806,7 +813,9 @@ (define-public python-asgi-lifespan
     (native-inputs (list python-pytest
                          python-pytest-asyncio
                          python-pytest-trio
-                         python-starlette))
+                         python-starlette
+                         python-setuptools
+                         python-wheel))
     (propagated-inputs (list python-sniffio))
     (home-page "https://github.com/florimondmanca/asgi-lifespan")
     (synopsis "Programmatic startup/shutdown of ASGI apps")
@@ -970,7 +979,9 @@ (define-public python-aws-xray-sdk
            python-pytest-benchmark
            python-requests
            python-sqlalchemy
-           python-webtest))
+           python-webtest
+           python-setuptools
+           python-wheel))
     (propagated-inputs
      (list python-aiohttp
            python-botocore
@@ -1310,7 +1321,9 @@ (define-public python-httplib2
            python-pytest-randomly
            python-pytest-timeout
            python-pytest-xdist
-           python-six))
+           python-six
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/httplib2/httplib2")
     (synopsis "Comprehensive HTTP client library")
     (description
@@ -1706,7 +1719,7 @@ (define-public python-h11
         (base32 "17b97c56y31hi0n0x0cb5a87x4xr9jijf2y06pzj0977k6zgn6cg"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/python-hyper/h11")
     (synopsis "Pure-Python, bring-your-own-I/O implementation of HTTP/1.1")
     (description
@@ -2165,7 +2178,9 @@ (define-public python-omnipath
            python-pytest-socket
            python-requests-mock
            python-setuptools-scm
-           python-tox))
+           python-tox
+           python-setuptools
+           python-wheel))
     (home-page "https://omnipathdb.org/")
     (synopsis "Python client for the OmniPath web service")
     (description "This package provides a Python client for the OmniPath web
@@ -2195,7 +2210,7 @@ (define-public python-openai
     (propagated-inputs (list python-aiohttp python-requests python-tqdm
                              python-typing-extensions))
     (native-inputs (list python-black python-pytest python-pytest-asyncio
-                         python-pytest-mock))
+                         python-pytest-mock python-setuptools python-wheel))
     (home-page "https://github.com/openai/openai-python")
     (synopsis "Python client library for the OpenAI API")
     (description "This package provides a Python client library for the
@@ -2400,7 +2415,7 @@ (define-public python-cssutils
                                      "and not encutils "
                                      "and not website.logging")))))))
     (native-inputs
-     (list python-pytest python-jaraco-test))
+     (list python-pytest python-jaraco-test python-setuptools python-wheel))
     (home-page "https://github.com/jaraco/cssutils")
     (synopsis
       "CSS Cascading Style Sheets library for Python")
@@ -2578,7 +2593,7 @@ (define-public python-wsproto
         (base32 "0rahm1j9danv1l6i6as80acwv16ycihxkhrvwjiqh9drxhk5ymmd"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (propagated-inputs
      (list python-h11))
     (home-page "https://github.com/python-hyper/wsproto/")
@@ -4503,7 +4518,7 @@ (define-public python-flask-compress
                 "178jzz6jxlxllcjqamzh5q7ahfh90m5cl1il9vmjs3xhz65z35pf"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-brotli python-flask))
-    (native-inputs (list python-setuptools-scm))
+    (native-inputs (list python-setuptools-scm python-setuptools python-wheel))
     (home-page "https://github.com/colour-science/flask-compress")
     (synopsis "Compress responses in a Flask app")
     (description
@@ -4526,6 +4541,7 @@ (define-public python-flask-seasurf
     (arguments
      (list #:tests? #false)) ;there are none
     (propagated-inputs (list python-flask))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/maxcountryman/flask-seasurf/")
     (synopsis "CSRF extension for Flask")
     (description "SeaSurf is a Flask extension for preventing cross-site
@@ -4961,7 +4977,7 @@ (define-public python-flask-jwt
                             "flask_jwt/__init__.py")
                (("access_token.decode\\('utf-8'\\)") "access_token")))))))
     (propagated-inputs (list python-flask python-pyjwt))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/mattupstate/flask-jwt")
     (synopsis "JWT token authentication for Flask apps")
     (description "This package implements JWT token authentication for Flask
@@ -4988,7 +5004,9 @@ (define-public python-flask-restful
     (native-inputs
      (list python-blinker
            python-mock
-           python-pytest))
+           python-pytest
+           python-setuptools
+           python-wheel))
     (home-page "https://www.github.com/flask-restful/flask-restful/")
     (synopsis "Flask module for creating REST APIs")
     (description
@@ -5654,9 +5672,9 @@ (define-public python-paste
            (delete-file "tests/test_proxy.py") #t))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest python-nose))
+     (list python-pytest python-wheel))
     (propagated-inputs
-     (list python-six))
+     (list python-six python-setuptools))
     (home-page "https://pythonpaste.readthedocs.io/")
     (synopsis
      "Python web development tools, focusing on WSGI")
@@ -5929,6 +5947,7 @@ (define-public whoogle-search
            python-stem
            python-validators
            python-waitress))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/benbusby/whoogle-search")
     (synopsis "Self-hosted, ad-free, privacy-respecting metasearch engine")
     (description
@@ -6026,7 +6045,7 @@ (define-public python-hyperlink
                    ;; Pretend to be a CI system to skip flaky tests.
                    (setenv "CI" "true"))))))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (propagated-inputs
      (list python-idna))
     (home-page "https://github.com/python-hyper/hyperlink")
@@ -6810,7 +6829,9 @@ (define-public python-httpcore
            python-pytest-httpbin
            python-pytest-trio
            python-uvicorn
-           python-trustme))
+           python-setuptools
+           python-trustme
+           python-wheel))
     (propagated-inputs
      (list python-anyio
            python-certifi
@@ -6844,7 +6865,7 @@ (define-public python-httpcore-bootstrap
    (package/inherit python-httpcore
      (name "python-httpcore-bootstrap")
      (arguments (list #:tests? #f))
-     (native-inputs '()))))
+     (native-inputs (list python-setuptools python-wheel)))))
 
 (define-public python-httpx
   (package
@@ -6889,7 +6910,9 @@ (define-public python-httpx
            python-trio
            python-trio-typing
            python-trustme
-           python-uvicorn))
+           python-uvicorn
+           python-setuptools
+           python-wheel))
     (propagated-inputs
      (list python-charset-normalizer
            python-brotli
@@ -7121,7 +7144,7 @@ (define-public python-rapidjson
                                 "/include/rapidjson" "'"))
                 (("if not os.path.isdir.*") "if False:")))))))
     (native-inputs
-     (list rapidjson python-pytest python-pytz))
+     (list rapidjson python-pytest python-pytz python-setuptools python-wheel))
     (home-page "https://github.com/python-rapidjson/python-rapidjson")
     (synopsis "Python wrapper around rapidjson")
     (description "This package provides a python wrapper around rapidjson.")
diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index 3a63c4ef80..2726725707 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -514,7 +514,8 @@ (define-public python-janus
         (base32 "04hnrdcf03g1s0x3sr72sh9gnszz6kyfsl9dg8a4n0zvvhn6z5yz"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest python-pytest-cov python-pytest-asyncio))
+     (list python-pytest python-pytest-cov python-pytest-asyncio
+           python-setuptools python-wheel))
     (propagated-inputs (list python-typing-extensions))
     (home-page "https://github.com/aio-libs/janus/")
     (synopsis
@@ -977,6 +978,7 @@ (define-public python-fit-nbinom
              (substitute* "setup.py"
                ((".\\*\"") "\"")))))))
     (propagated-inputs (list python-numpy python-scipy))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/joachimwolff/fit_nbinom")
     (synopsis "Negative binomial maximum likelihood estimator")
     (description "This package provides an implementation in Python using
@@ -995,7 +997,8 @@ (define-public python-docrep
                 "0523jrzjj29kxpdllmfhrfj9kysi9mphp2m7ippjkn5b07i1g2pd"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-six))
-    (native-inputs (list python-pytest python-pytest-runner))
+    (native-inputs (list python-pytest python-pytest-runner
+                         python-setuptools python-wheel))
     (home-page "https://github.com/Chilipp/docrep")
     (synopsis "Python package for docstring repetition")
     (description "Docrep is the documentation repetition module.  This module
@@ -1073,6 +1076,7 @@ (define-public python-adjusttext
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false)) ;there are none
     (propagated-inputs (list python-matplotlib python-numpy))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/Phlya/adjustText")
     (synopsis "Adjust text position in matplotlib plots to minimize overlaps")
     (description
@@ -1234,6 +1238,7 @@ (define-public python-colored
                 "196ins0m7f90xz5dw764dlx060ziqbcydqzzq40b4ir5858baf3r"))))
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false)) ;the tests are not run automatically
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://gitlab.com/dslackw/colored")
     (synopsis "Simple library for color and formatting to terminal")
     (description "This is a very simple Python library for color and
@@ -1256,7 +1261,8 @@ (define-public python-colorful
         (base32 "0kyy9qhvrb5m9h8xmri7c88i0k1g5qc7017anw39gx44an7mn33y"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-coverage python-flake8 python-pytest))
+     (list python-coverage python-flake8 python-pytest python-setuptools
+           python-wheel))
     (propagated-inputs
      (list python-colorama))
     (home-page "http://github.com/timofurrer/colorful")
@@ -1697,7 +1703,8 @@ (define-public python-pdoc
                (base32
                 "0gxkw607nrd67ck4w8jri9vfrm5g60qvp8b134m8zkiphbxjnx0l"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest python-jinja2 python-pygments))
+    (native-inputs (list python-pytest python-jinja2 python-pygments
+                         python-setuptools python-wheel))
     (arguments
      (list
       ;; Some tests fail, presumably because of slight version mismatches of
@@ -1804,6 +1811,7 @@ (define-public python-plotext
                 "1gpy1z2i4vq1mcrhysxahz4339pbl9rzk58rf5m5gf5ym9xji6ii"))))
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false)) ;there are none
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/piccolomo/plotext")
     (synopsis "Plots in the terminal")
     (description "Plotext lets you plot directly to the terminal.")
@@ -1998,6 +2006,8 @@ (define-public python-skranger
            python-matplotlib
            python-pandas
            python-poetry-core
+           python-setuptools
+           python-wheel
            python-pytest))
     (home-page "https://github.com/crflynn/skranger")
     (synopsis "Python bindings for C++ ranger random forests")
@@ -2165,7 +2175,7 @@ (define-public python-tenacity
     (build-system pyproject-build-system)
     (native-inputs
      (list python-setuptools-scm python-tornado-6 python-typeguard
-           python-pytest))
+           python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/jd/tenacity")
     (synopsis "Retrying library for python")
     (description "Tenacity is a general-purpose python library to simplify the
@@ -2650,7 +2660,7 @@ (define-public python-rasterio
                              python-click-plugins
                              python-cligj
                              python-numpy
-                             python-setuptools
+                             python-setuptools ; For pkg_resources.
                              python-snuggs))
     (native-inputs (list gdal
                          python-boto3
@@ -2659,7 +2669,8 @@ (define-public python-rasterio
                          python-packaging
                          python-pytest
                          python-pytest-cov
-                         python-shapely))
+                         python-shapely
+                         python-wheel))
     (home-page "https://github.com/rasterio/rasterio")
     (synopsis "Fast and direct raster I/O for use with Numpy and SciPy")
     (description "This package implements fast and direct raster I/O for use
@@ -2686,7 +2697,7 @@ (define-public python-shapely
              ;; Cython extensions have to be built before running the tests.
              (invoke "python" "setup.py" "build_ext" "--inplace"))))))
     (native-inputs
-     (list python-cython python-matplotlib python-pytest))
+     (list python-cython python-matplotlib python-pytest python-setuptools python-wheel))
     (inputs
      (list geos))
     (propagated-inputs
@@ -2972,7 +2983,9 @@ (define-public python-h5netcdf
     (native-inputs
      (list python-netcdf4
            python-pytest
-           python-setuptools-scm))
+           python-setuptools
+           python-setuptools-scm
+           python-wheel))
     (propagated-inputs
      (list python-h5py python-packaging))
     (home-page "https://h5netcdf.org")
@@ -3314,7 +3327,7 @@ (define-public python-license-expression
         (base32 "0lvshl2fhwa568d3y3vmx45hdp8gk5w9yl3b2q5d66r5vqn1sfwl"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-setuptools-scm python-pytest))
+     (list python-setuptools-scm python-pytest python-setuptools python-wheel))
     (propagated-inputs
      (list python-boolean.py))
     (home-page "https://github.com/nexB/license-expression")
@@ -3436,7 +3449,8 @@ (define-public python-filelock-3.5
         (base32
          "058av1r760ws7z6qffsjpqa39fmdxw0s1wnyr7p50y3zclg6cyqk"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest python-setuptools-scm))
+    (native-inputs (list python-pytest python-setuptools-scm
+                         python-setuptools python-wheel))
     (home-page "https://github.com/tox-dev/py-filelock")
     (synopsis "Platform independent file lock")
     (description "@code{filelock} contains a single module implementing
@@ -3720,7 +3734,8 @@ (define-public python-can
          ;; These tests fail with "OSError: [Errno 19] No such device".
          "-k" "not BasicTestUdpMulticastBusIPv")))
     (propagated-inputs
-     (list python-msgpack python-typing-extensions python-wrapt))
+     (list python-msgpack python-typing-extensions python-wrapt
+           python-setuptools))
     (native-inputs
      (list ;; python-canalystii ; Not packed yet
            python-codecov
@@ -3733,7 +3748,8 @@ (define-public python-can
            python-pytest
            python-pytest-cov
            python-pytest-runner
-           python-pytest-timeout))
+           python-pytest-timeout
+           python-wheel))
     (home-page "https://github.com/hardbyte/python-can")
     (synopsis "Controller Area Network (CAN) interface module for Python")
     (description "This package defines the @code{can} module, which provides
@@ -3868,6 +3884,7 @@ (define-public python-optparse-pretty
         (base32 "1920wbh2b7a8qn7zx2iiqbcdaax335l81a73x9pp8h11yzs2jdmh"))))
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false))  ;There are none
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/gvalkov/optparse-pretty")
     (synopsis "Compact help formatter for optparse")
     (description
@@ -4078,6 +4095,7 @@ (define-public python-fastprogress
                         ;; XXX: Fails with: "In procedure utime: No such file
                         ;; or directory".
                         (delete 'ensure-no-mtimes-pre-1980))))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/fastai/fastprogress")
     (synopsis "Progress bar for Jupyter Notebook and console")
     (description
@@ -4311,6 +4329,8 @@ (define-public python-omero-py
            python-pytest
            python-pytest-rerunfailures
            python-pytest-xdist
+           python-setuptools
+           python-wheel
            unzip
            (origin
              (method url-fetch)
@@ -4673,7 +4693,9 @@ (define-public python-jsonargparse
            python-pytest-subtests
            python-responses
            python-tox
-           python-types-requests))
+           python-types-requests
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/omni-us/jsonargparse/")
     (synopsis "Implement minimal boilerplate CLIs derived from type hints")
     (description
@@ -4902,7 +4924,7 @@ (define-public python-palettable
                (base32
                 "1a4h0jpsr3wjciqg9a5kslxv65d3qqgmqgkpai4cl77wlpcxfk89"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://jiffyclub.github.io/palettable/")
     (synopsis "Color palettes for Python")
     (description "Palettable (formerly brewer2mpl) is a library of color
@@ -4983,7 +5005,8 @@ (define-public python-parsley
                            (string-append "not test_sending_empty_netstring"
                             " and not test_sending_one_netstring"
                             " and not test_sending_two_netstrings"))))
-    (native-inputs (list python-pytest python-twisted))
+    (native-inputs (list python-pytest python-twisted python-setuptools
+                         python-wheel))
     (home-page "https://launchpad.net/parsley")
     (synopsis "Parsing and pattern matching Python library")
     (description
@@ -5134,7 +5157,9 @@ (define-public python-portalocker
                          python-pytest-cov
                          python-pytest-mypy
                          python-pytest-timeout
-                         python-redis))
+                         python-redis
+                         python-setuptools
+                         python-wheel))
     (home-page "https://github.com/WoLpH/portalocker")
     (synopsis "Python library for file locking")
     (description "Portalocker is a library to provide an easy API to file
@@ -5242,14 +5267,16 @@ (define-public python-extension-helpers
            python-pytest-astropy
            python-pytest-cov
            python-setuptools-scm
-           python-tomli))
+           python-tomli
+           python-setuptools
+           python-wheel))
     (home-page "https://extension-helpers.readthedocs.io")
     (synopsis "Astropy ecosystem utilities for building and installing packages")
     (description
-     "The extension-helpers package includes convenience helpers to assist with
-building Python packages with compiled C/Cython extensions.  It is developed by
-the Astropy project but is intended to be general and usable by any Python
-package.")
+     "The extension-helpers package includes convenience helpers to assist
+with building Python packages with compiled C/Cython extensions.  It is
+developed by the Astropy project but is intended to be general and usable by
+any Python package.")
     (license license:bsd-3)))
 
 (define-public python-extras
@@ -5737,12 +5764,14 @@ (define-public python-clickhouse-connect
            python-orjson
            python-pandas
            python-pytz
+           python-setuptools ; For pkg_resources.
            python-sqlalchemy
            python-urllib3
            python-zstandard))
     (native-inputs
      (list python-cython
-           python-pytest))
+           python-pytest
+           python-wheel))
     (home-page "https://github.com/ClickHouse/clickhouse-connect")
     (synopsis
      "ClickHouse database core driver for Python, Pandas, and Superset")
@@ -5787,7 +5816,7 @@ (define-public python-cloup
                 "05c6cjpnf9s72gyn5dckxbmd8rf2kgdzfsl7pqzrnc1lcdl13zmv"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-click))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/janLuke/cloup")
     (synopsis "Extension library for python-click")
     (description
@@ -5915,7 +5944,8 @@ (define-public python-jsonschema
               (when tests?
                 (setenv "JSON_SCHEMA_TEST_SUITE" "json")
                 (invoke "trial" "jsonschema")))))))
-    (native-inputs (list python-setuptools-scm python-twisted))
+    (native-inputs (list python-setuptools-scm python-twisted
+                         python-setuptools python-wheel))
     (propagated-inputs
      (list python-attrs
            python-importlib-metadata
@@ -6118,7 +6148,9 @@ (define-public python-pyjwt
            python-cryptography
            python-pytest
            python-sphinx
-           python-sphinx-rtd-theme))
+           python-sphinx-rtd-theme
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/progrium/pyjwt")
     (synopsis "JSON Web Token implementation in Python")
     (description
@@ -6366,7 +6398,7 @@ (define-public python-uc-micro-py
                (base32
                 "17f55gi55rg47nm88fn3f8851ph03dgykdp011lxr3j6hk18lyfv"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/tsutsu3/uc.micro-py")
     (synopsis "Unicode data files for linkify-it-py projects")
     (description "This package contains a micro subset of Unicode data files
@@ -6388,7 +6420,7 @@ (define-public python-linkify-it-py
                 "0fg0a1lc8xbb62y9krxcp708ll58dxcwm8i7rrwpkd5sh2229f6x"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-uc-micro-py))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/tsutsu3/linkify-it-py")
     (synopsis "Links recognition library with full Unicode support")
     (description "This is Python port of
@@ -6413,7 +6445,7 @@ (define-public python-makefun
                 "19a8dga8rnmjn5gy1cy1wdi28swbkdkypwbqikbxil6ynqcg3c20"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest python-setuptools-scm))
+     (list python-pytest python-setuptools python-setuptools-scm python-wheel))
     (home-page "https://github.com/smarie/python-makefun")
     (synopsis "Library to dynamically create python functions")
     (description "@code{makefun} helps create functions dynamically with a
@@ -7091,8 +7123,8 @@ (define-public python-docx
      (list behave
            python-pyparsing
            python-pytest
-           python-pytest-cov
-           python-pytest-xdist))
+           python-setuptools
+           python-wheel))
     (propagated-inputs
      (list python-lxml python-typing-extensions))
     (home-page "https://github.com/python-openxml/python-docx/")
@@ -7235,7 +7267,7 @@ (define-public python-pygments
       ;; basic tests.
       '(list "--ignore-glob=tests/*/*")))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://pygments.org/")
     (synopsis "Syntax highlighting")
     (description
@@ -7290,6 +7322,7 @@ (define-public python-pygtrie
                (base32
                 "1qm4xdmzd4q5pc9h5gjdpr5m7lg06k8dvqnjn7d07d3fhani8d90"))))
     (build-system pyproject-build-system)
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/mina86/pygtrie")
     (synopsis "Pure Python trie data structure implementation")
     (description
@@ -9015,7 +9048,7 @@ (define-public python-pygit2
         (base32 "1v34xdvh6i5cn5srwicvp0i2kvv8fzsv0v9p72ng081nsczmhgvr"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-cffi libgit2))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/libgit2/pygit2")
     (synopsis "Python bindings for libgit2")
     (description "Pygit2 is a set of Python bindings to the libgit2 shared library.")
@@ -9228,7 +9261,9 @@ (define-public python-norns
                (base32
                 "1r1lcq59v6l75wkbp7mypanr69a6fv6m58v6dw3v6b4vwz5nqg0z"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-appdirs python-nose python-pyyaml))
+    (propagated-inputs (list python-appdirs python-nose python-pyyaml
+                             python-setuptools))
+    (native-inputs (list python-wheel))
     (home-page "https://github.com/simonvh/norns")
     (synopsis "Simple YAML-based config module")
     (description "This package provides a simple YAML-based config module.")
@@ -10223,7 +10258,7 @@ (define-public python-distlib
               ;; NOTE: Any value works, the variable just has to be present.
               (setenv "SKIP_ONLINE" "1"))))))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (inputs
      (list bash-minimal))
     (home-page "https://github.com/pypa/distlib")
@@ -10963,10 +10998,10 @@ (define-public python-imageio
               (delete-file "tests/test_freeimage.py"))))))
     (inputs (list freeimage))
     (propagated-inputs
-     (list python-imageio-ffmpeg python-numpy python-pillow python-tifffile))
+     (list python-imageio-ffmpeg python-numpy python-pillow python-tifffile python-setuptools))
     (native-inputs
      (list python-black python-flake8 python-fsspec python-pytest
-           python-pytest-cov))
+           python-pytest-cov python-wheel))
     (home-page "https://imageio.github.io/")
     (synopsis "Library for reading and writing a wide range of image data")
     (description
@@ -12183,7 +12218,9 @@ (define-public python-jaraco-test
                          python-pytest-cov
                          python-pytest-enabler
                          python-pytest-flake8
-                         python-pytest-mypy))
+                         python-pytest-mypy
+                         python-setuptools
+                         python-wheel))
     (home-page "https://github.com/jaraco/jaraco.test")
     (synopsis "Testing support by jaraco")
     (description "This package provides testing support by jaraco.")
@@ -12631,6 +12668,7 @@ (define-public python-jupyter-client-bootstrap
             python-pyzmq
             python-tornado-6
             python-traitlets))
+     (native-inputs (list python-setuptools python-wheel))
      (home-page "https://jupyter.org/")
      (synopsis "Jupyter protocol implementation and client libraries")
      (description
@@ -12668,7 +12706,9 @@ (define-public python-jupyter-client
              python-pytest-timeout
              python-async-generator
              python-ipython
-             python-ipykernel-bootstrap))
+             python-ipykernel-bootstrap
+             python-setuptools
+             python-wheel))
       (properties (alist-delete 'hidden? (package-properties base))))))
 
 (define-public python-ipykernel
@@ -12744,7 +12784,9 @@ (define-public python-ipykernel
            ;; and causes deprecation warnings.  Using the bootstrap variant
            ;; avoids that.
            python-pytest-bootstrap
-           python-pytest-timeout))
+           python-pytest-timeout
+           python-setuptools
+           python-wheel))
     (home-page "https://ipython.org")
     (synopsis "IPython Kernel for Jupyter")
     (description "This package provides the IPython kernel for Jupyter.")
@@ -12763,7 +12805,7 @@ (define-public python-ipykernel-bootstrap
                          ;; left out here to break the cycle.
                          #:phases #~(modify-phases %standard-phases
                                       (delete 'sanity-check))))
-        (native-inputs '())
+        (native-inputs (list python-setuptools python-wheel))
         (propagated-inputs
          (modify-inputs (package-propagated-inputs parent)
            (replace "python-jupyter-client" python-jupyter-client-bootstrap)
@@ -12833,7 +12875,9 @@ (define-public python-pubmed-parser
            python-unidecode))
     (native-inputs
      (list python-pytest
-           python-pytest-cov))
+           python-pytest-cov
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/titipata/pubmed_parser")
     (synopsis "Parser for Pubmed Open-Access Subset and MEDLINE XML repository")
     (description
@@ -14266,6 +14310,7 @@ (define-public python-qnorm
                  "{ name = \"Maarten van der Sande\", email = \"maartenvandersande@hotmail.com\"}")
                 (("license = \"MIT\"") "license = { file = \"LICENSE\"}")))))))
     (propagated-inputs (list python-numba python-numpy python-pandas))
+    (native-inputs (list python-setuptools python-wheel python-toml))
     (home-page "https://github.com/Maarten-vd-Sande/qnorm")
     (synopsis "Quantile normalization")
     (description "This tool implements quantile normalization. It properly
@@ -14326,7 +14371,9 @@ (define-public python-singledispatch
     (build-system pyproject-build-system)
     (native-inputs
      (list python-pytest
-           python-six)) ; required for conversion, not at run-time
+           python-setuptools
+           python-six ; required for conversion, not at run-time
+           python-wheel))
     (home-page
      "https://docs.python.org/3/library/functools.html#functools.singledispatch")
     (synopsis "Backport of singledispatch feature from Python 3.4")
@@ -14762,7 +14809,8 @@ (define-public python-pyproject-metadata
          "0yvs59ymz5gdix34a95wxlxvk9bnvjgrzsnmnc3ws7whpfv3yasm"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-packaging))
-    (native-inputs (list python-pypa-build python-pytest python-tomli))
+    (native-inputs (list python-pypa-build python-pytest python-setuptools
+                         python-tomli python-wheel))
     (home-page "https://github.com/FFY00/python-pyproject-metadata")
     (synopsis "Dataclass for PEP 621 metadata")
     (description "This project does not implement the parsing of
@@ -15595,7 +15643,8 @@ (define-public python-pyftpdlib
     ;; Using Pytest instead of the Makefile causes the command line tests to
     ;; fail on unknown Pytest arguments.
     (arguments (list #:test-flags #~(list "-k" "not TestCommandLineParser")))
-    (native-inputs (list python-psutil python-pytest))
+    (native-inputs (list python-psutil python-pytest python-setuptools
+                         python-wheel))
     (propagated-inputs (list python-pyopenssl python-pysendfile))
     (home-page "https://github.com/giampaolo/pyftpdlib/")
     (synopsis "Asynchronous and scalable Python FTP server library")
@@ -16386,7 +16435,8 @@ (define-public python-snuggs
                 "0yv1wayrw9g6k0c2f721kha7wsv0s1fdlxpf5x7f34iqzq9z272h"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-numpy python-pyparsing))
-    (native-inputs (list python-hypothesis python-pytest))
+    (native-inputs (list python-hypothesis python-pytest python-setuptools
+                         python-wheel))
     (home-page "https://github.com/mapbox/snuggs")
     (synopsis "Snuggs are S-expressions for Numpy")
     (description "Snuggs are S-expressions for Numpy.")
@@ -16873,7 +16923,7 @@ (define-public python-path-bootstrap
      (build-system pyproject-build-system)
      (arguments
       (list #:tests? #f))
-     (native-inputs (list python-setuptools-scm))
+     (native-inputs (list python-setuptools python-setuptools-scm python-wheel))
      (home-page "https://github.com/jaraco/path")
      (synopsis "Object-oriented file system path manipulation library")
      (description "@code{path} (formerly @code{path.py}) implements path
@@ -17531,7 +17581,9 @@ (define-public python-fastjsonschema
            python-pylint
            python-pytest
            python-pytest-benchmark
-           python-pytest-cache))
+           python-pytest-cache
+           python-setuptools
+           python-wheel))
     (home-page
      "https://github.com/horejsek/python-fastjsonschema")
     (synopsis
@@ -17614,7 +17666,7 @@ (define-public python-bleach
             (delete-file-recursively "bleach/_vendor/html5lib")))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-html5lib python-tinycss2))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/mozilla/bleach")
     (synopsis "Whitelist-based HTML-sanitizing tool")
     (description "Bleach is an easy whitelist-based HTML-sanitizing tool.")
@@ -18150,7 +18202,7 @@ (define-public python-chardet
         (base32
          "1r9ixxnish9j3dq4h0z0cwlkr4f5lgi6d8mhbzw59hbbjlmp2qhd"))))
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (build-system pyproject-build-system)
     (arguments
      (list #:test-flags
@@ -18364,7 +18416,7 @@ (define-public python-confection
     (build-system pyproject-build-system)
     (propagated-inputs (list python-pydantic python-srsly
                              python-typing-extensions))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/explosion/confection")
     (synopsis "Config system for Python")
     (description "Confection is a lightweight library that offers a
@@ -18431,7 +18483,8 @@ (define-public python-omegaconf
     (propagated-inputs (list java-antlr4-runtime-python
                              python-pydevd
                              python-pyyaml))
-    (native-inputs (list icedtea antlr4 python-pytest python-pytest-mock))
+    (native-inputs (list icedtea antlr4 python-pytest python-pytest-mock
+                         python-setuptools python-wheel))
     (home-page "https://github.com/omry/omegaconf")
     (synopsis "Flexible configuration system")
     (description "OmegaConf is a hierarchical configuration system and
@@ -18450,10 +18503,10 @@ (define-public python-configargparse
                (base32
                 "1l866g1dcf2ljf8fl7ggpxk1rggry0lya4d5b264gradi1qp81p7"))))
     (build-system pyproject-build-system)
-    (native-inputs
-     (list python-mock python-pytest))
     (propagated-inputs
      (list python-pyyaml))
+    (native-inputs
+     (list python-mock python-pytest python-setuptools python-wheel))
     (synopsis "Replacement for argparse")
     (description "A drop-in replacement for argparse that allows options to also
 be set via config files and/or environment variables.")
@@ -19600,6 +19653,7 @@ (define-public python-xdg
                (base32
                 "14hwk9j5zjc8rvirw95mrb07zdnpjaxjx2mj3rnq8pnlyaa809r4"))))
     (build-system pyproject-build-system)
+    (arguments (list #:tests? #f)) ; No tests in PyPi tarball.
     (native-inputs
      (list python-poetry-core))
     (home-page "https://github.com/srstevenson/xdg-base-dirs")
@@ -20118,7 +20172,8 @@ (define-public python-cesium
            python-scikit-learn
            python-scipy
            python-toolz))
-    (native-inputs (list python-cython python-pytest python-setuptools-scm))
+    (native-inputs (list python-cython python-pytest python-setuptools-scm
+                         python-setuptools python-wheel))
     (home-page "https://pypi.org/project/cesium/")
     (synopsis "Library for time-series feature extraction and processing")
     (description
@@ -20195,7 +20250,8 @@ (define-public python-pyqtgraph
                  (lambda _
                    (setenv "QT_QPA_PLATFORM" "offscreen"))))))
     (native-inputs
-     (list python-pytest python-pytest-cov python-pytest-xdist))
+     (list python-pytest python-pytest-cov python-pytest-xdist
+           python-setuptools python-wheel))
     (inputs
      (list qtbase-5))
     (propagated-inputs
@@ -20383,7 +20439,9 @@ (define-public python-codespell
             python-pytest
             python-pytest-cov
             python-pytest-dependency
-            python-tomli))
+            python-tomli
+            python-setuptools
+            python-wheel))
     (arguments
      `(#:phases
        (modify-phases %standard-phases
@@ -21517,7 +21575,9 @@ (define-public python-inflect
                          python-pytest-flake8
                          python-pytest-mypy
                          ;; For the version number
-                         python-setuptools-scm))
+                         python-setuptools-scm
+                         python-setuptools
+                         python-wheel))
     (home-page "https://github.com/jaraco/inflect")
     (synopsis "Correctly generate plurals, singular nouns, ordinals, indefinite articles")
     (description
@@ -23789,7 +23849,8 @@ (define-public python-xopen
     (propagated-inputs
      (list pigz python-isal python-typing-extensions))
     (native-inputs
-     (list python-pytest python-pytest-timeout python-setuptools-scm))
+     (list python-pytest python-pytest-timeout python-setuptools-scm
+           python-setuptools python-wheel))
     (home-page "https://github.com/marcelm/xopen/")
     (synopsis "Open compressed files transparently")
     (description "This module provides an @code{xopen} function that works
@@ -23873,6 +23934,7 @@ (define-public python-chevron
                 "1gqfh00ics2k1sm5g46l3bi8cl5fc5d1cwzh1ylvcxvdvypklqc7"))))
     (build-system pyproject-build-system)
     (arguments (list #:tests? #false)) ;there are none
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/noahmorrison/chevron")
     (synopsis "Mustache templating language renderer")
     (description "This package provides a Python implementation of the
@@ -23935,7 +23997,9 @@ (define-public python-duckdb
            python-pyarrow
            python-pytest
            python-pytest-runner
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page "https://www.duckdb.org")
     (synopsis "DuckDB embedded database")
     (description "DuckDB is an in-process SQL OLAP database management
@@ -24856,6 +24920,7 @@ (define-public python-diff-cover
            python-jinja2
            python-pluggy
            python-pygments
+           python-setuptools ; For pkg_resources.
            python-tomli))
     (native-inputs
      (list python-flake8
@@ -25070,7 +25135,8 @@ (define-public python-gtts
      ;; Disable tests that require internet.
      (list #:test-flags '(list "-k" "not net")))
     (native-inputs
-     (list python-pytest python-testfixtures python-click python-requests))
+     (list python-pytest python-testfixtures python-click python-requests
+           python-setuptools python-wheel))
     (home-page "https://github.com/pndurette/gTTS")
     (synopsis "Google Translate text-to-speech interface")
     (description
@@ -25601,7 +25667,9 @@ (define-public python-marshmallow
            python-mypy
            python-pytest
            python-pytz
-           python-simplejson))
+           python-simplejson
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/marshmallow-code/marshmallow")
     (synopsis "Convert complex datatypes to and from native Python datatypes")
     (description "@code{marshmallow} provides a library for converting complex
@@ -25663,7 +25731,9 @@ (define-public python-apispec
            python-marshmallow
            python-mypy
            python-pytest
-           python-pyyaml))
+           python-pyyaml
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/marshmallow-code/apispec")
     (synopsis "Swagger/OpenAPI specification generator")
     (description "@code{python-apispec} is a pluggable API specification
@@ -25682,7 +25752,7 @@ (define-public python-apispec-webframeworks
                (base32
                 "1wyw30402xq2a8icrsjmy9v43jyvawcjd85ccb2zicqlg4k5pcqd"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-apispec))
+    (propagated-inputs (list python-apispec python-setuptools))
     (native-inputs
      (list python-bottle
            python-flake8
@@ -25692,7 +25762,8 @@ (define-public python-apispec-webframeworks
            python-pytest
            python-pyyaml
            python-tornado
-           python-tox))
+           python-tox
+           python-wheel))
     (home-page "https://github.com/marshmallow-code/apispec-webframeworks")
     (synopsis "Web framework plugins for apispec")
     (description "This package provides plugins for using @code{apispec} with
@@ -26412,7 +26483,9 @@ (define-public python-tempora
            python-pytest-mypy
            python-setuptools-scm
            python-types-freezegun
-           python-types-pytz))
+           python-types-pytz
+           python-setuptools
+           python-wheel))
     (propagated-inputs (list python-jaraco-functools python-pytz))
     (home-page "https://github.com/jaraco/tempora")
     (synopsis "Python date and time objects and routines")
@@ -26536,7 +26609,9 @@ (define-public python-zict
      (list python-pytest
            python-pytest-asyncio
            python-pytest-repeat
-           python-pytest-timeout))
+           python-pytest-timeout
+           python-setuptools
+           python-wheel))
     (home-page "https://zict.readthedocs.io/en/latest/")
     (synopsis "Composable mutable mapping tools")
     (description "This package provides abstract @code{MutableMapping} classes
@@ -26726,7 +26801,7 @@ (define-public python-whatever
         (base32 "1q7ajgqjfivxqsqgnhp4lc4p6jxyh4zprcsdbpd6dw54inaf0av5"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/Suor/whatever")
     (synopsis "Make anonymous functions by partial application of operators")
     (description "@code{whatever} provides an easy way to make anonymous
@@ -26748,7 +26823,7 @@ (define-public python-funcy
        (file-name (git-file-name name version))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest python-whatever))
+     (list python-pytest python-whatever python-setuptools python-wheel))
     (home-page "https://github.com/Suor/funcy")
     (synopsis "Functional tools")
     (description "@code{funcy} is a library that provides functional tools.
@@ -27227,7 +27302,7 @@ (define-public python-pybloom-live
                 "040i6bjqvl33j30v865shsk30s3h7f16pqwiaj5kig857dfmqm4r"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-bitarray python-xxhash))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/joseph-fox/python-bloomfilter")
     (synopsis "Bloom filter")
     (description "This package provides a scalable Bloom filter implemented in
@@ -28392,7 +28467,8 @@ (define-public python-numcodecs
            python-msgpack
            python-typing-extensions))
     (native-inputs
-     (list python-cython python-pytest python-setuptools-scm))
+     (list python-cython python-pytest python-setuptools-scm
+           python-setuptools python-wheel))
     (home-page "https://github.com/zarr-developers/numcodecs")
     (synopsis "Buffer compression and transformation codecs")
     (description
@@ -28518,6 +28594,7 @@ (define-public python-anndata
            python-pandas
            python-scipy
            python-scikit-learn
+           python-setuptools ; For pkg_resources.
            python-zarr))
     (native-inputs
      (list python-awkward
@@ -28564,7 +28641,7 @@ (define-public python-dill
                (with-directory-excursion "/tmp"
                  (invoke "nosetests" "-v"))))))))
     (native-inputs
-     (list python-nose))
+     (list python-nose python-setuptools python-wheel))
     (home-page "https://pypi.org/project/dill/")
     (synopsis "Serialize all of Python")
     (description "Dill extends Python's @code{pickle} module for serializing
@@ -28616,6 +28693,7 @@ (define-public python-multiprocess
                (invoke "python" "-m" "multiprocess.tests")))))))
     (propagated-inputs
      (list python-dill))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://pypi.org/project/multiprocess/")
     (synopsis "Multiprocessing and multithreading in Python")
     (description
@@ -28928,7 +29006,8 @@ (define-public python-fsspec
     (propagated-inputs
      (list python-aiohttp python-libarchive-c python-requests python-tqdm))
     (native-inputs
-     (list python-pytest python-pytest-mock python-numpy))
+     (list python-pytest python-pytest-mock python-numpy python-setuptools
+           python-wheel))
     (home-page "https://github.com/intake/filesystem_spec")
     (synopsis "File-system specification")
     (description "The purpose of this package is to produce a template or
@@ -29239,6 +29318,7 @@ (define-public python-absl-py
         (base32
          "0ga3b0m8lfsv1m3260p83lhis52yvz3d42q8gip4gfj823849hnj"))))
     (build-system pyproject-build-system)
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/abseil/abseil-py")
     (synopsis "Abseil Python common libraries")
     (description
@@ -29543,7 +29623,8 @@ (define-public python-trio-typing
        (sha256
         (base32 "15wa66cs165wawh4pi808ac43n67b8jqddi5ppdcbkj5gfi68hpi"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-attrs python-pytest))
+    (native-inputs (list python-attrs python-pytest python-setuptools
+                         python-wheel))
     (propagated-inputs
      (list python-mypy python-mypy-extensions python-trio
            python-typing-extensions))
@@ -30809,7 +30890,7 @@ (define-public python-funcparserlib
              (when tests?
                (invoke "python" "-m" "unittest" "discover" "-v")))))))
     ;; ModuleNotFoundError: No module named 'poetry'
-    (native-inputs (list python-poetry-core))
+    (native-inputs (list python-poetry-core python-six))
     (home-page "https://github.com/vlasovskikh/funcparserlib")
     (synopsis
      "Recursive descent parsing library based on functional combinators")
@@ -31085,7 +31166,9 @@ (define-public python-watchgod
            python-pytest-cov
            python-pytest-mock
            python-pytest-sugar
-           python-pytest-toolbox))
+           python-pytest-toolbox
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/samuelcolvin/watchgod")
     (synopsis "Simple, modern file watching and code reload in Python")
     (description
@@ -32486,7 +32569,7 @@ (define-public python-blessed
       ;; Avoid python-pytest-coverage
       #:test-flags '(list "-c /dev/null")))
     (propagated-inputs (list python-six python-wcwidth))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/jquast/blessed")
     (synopsis "Wrapper around terminal capabilities")
     (description
@@ -32761,7 +32844,8 @@ (define-public python-dateparser
      (list python-dateutil python-pytz python-regex python-ruamel.yaml
            python-tzlocal))
     (native-inputs
-     (list python-flake8 python-pytest python-parameterized tzdata-for-tests))
+     (list python-flake8 python-pytest python-parameterized tzdata-for-tests
+           python-setuptools python-wheel))
     (arguments
      `(#:phases
        (modify-phases %standard-phases
@@ -33662,7 +33746,9 @@ (define-public python-loguru
                          python-sphinx
                          python-sphinx-autobuild
                          python-sphinx-rtd-theme
-                         python-tox))
+                         python-tox
+                         python-setuptools
+                         python-wheel))
     (home-page "https://github.com/Delgan/loguru")
     (synopsis "Python logging made (stupidly) simple")
     (description "Python logging made (stupidly) simple")
@@ -36317,6 +36403,7 @@ (define-public python-types-requests
                 "0cas3cjkhrvsz2rmqnhqiihy9j79wxi9xbih8jk0p9r48c2q3iyy"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-types-urllib3))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/python/typeshed")
     (synopsis "Typing stubs for requests")
     (description "This package provides typing stubs for requests.")
@@ -36349,6 +36436,7 @@ (define-public python-types-urllib3
                (base32
                 "0zcipjdnbnc8ymk8mh9n5mypa0qr03rqj98lbmahldcdrrap6md1"))))
     (build-system pyproject-build-system)
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/python/typeshed")
     (synopsis "Typing stubs for urllib3")
     (description "This package provides typing stubs for urllib3.")
@@ -36366,6 +36454,7 @@ (define-public python-typeshed-client
                 "1vdwp1jjg27b22qxgm49v21nb8vm1iki3bfsm0fnq2rsz5alfwz2"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-importlib-resources))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/JelleZijlstra/typeshed_client")
     (synopsis "Library for accessing stubs in typeshed")
     (description
@@ -36782,7 +36871,9 @@ (define-public python-srsly
            python-pytest-timeout
            python-mock
            python-numpy
-           python-psutil))
+           python-psutil
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/explosion/srsly")
     (synopsis "Serialization utilities for Python")
     (description "This package bundles some of the best Python serialization
@@ -37034,7 +37125,7 @@ (define-public python-iteround
                (base32 "1irw4sqrsgpc0ibxdv1hlx0d0jr1fqs48bj6mpfylzqkag9ywlfj"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list python-pytest))
+     (list python-pytest python-setuptools python-wheel))
     (home-page "https://github.com/cgdeboer/iteround")
     (synopsis "Sum-safe rounding for Iterables")
     (description "Iteround is a standard library sum-safe rounding library for
@@ -37148,7 +37239,10 @@ (define-public python-deepdiff
            python-mock
            python-numpy
            python-pytest
-           python-pyyaml))
+           python-pyyaml
+           python-setuptools
+           python-wheel
+           python-toml))
     (home-page "https://github.com/seperman/deepdiff")
     (synopsis "Deep difference and search of any Python object/data")
     (description
@@ -37177,7 +37271,9 @@ (define-public python-deepmerge
               (setenv "SETUPTOOLS_SCM_PRETEND_VERSION" #$version))))))
     (native-inputs
      (list python-setuptools-scm
-           python-pytest))
+           python-pytest
+           python-setuptools
+           python-wheel))
     (home-page "https://deepmerge.readthedocs.io/en/latest/")
     (synopsis "Merge nested data structures")
     (description
@@ -37629,7 +37725,7 @@ (define-public python-cogapp
                (base32
                 "1c0xx3p3lzrlyqhmccyq9c50f8v9pqk2992gb4nl50h2yy1m3s8v"))))
     (build-system pyproject-build-system)
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (home-page "https://nedbatchelder.com/code/cog")
     (synopsis "Content generation tool that leverages Python")
     (description "Cog is a file generation tool.  It allows using pieces of
@@ -38070,7 +38166,10 @@ (define-public staticsite
            python-ruamel.yaml
            python-slugify
            python-tornado
-           tzdata-for-tests))
+           tzdata-for-tests
+           python-setuptools
+           python-wheel
+           python-toml))
     (home-page "https://github.com/spanezz/staticsite")
     (synopsis "Static site generator")
     (description "Statistic is a static site generator based on Markdown and
@@ -38163,8 +38262,9 @@ (define-public python-zbarlight
                (base32
                 "1v5c9bim8af6g8kgxp2dhm96n5vkr8sqi56w0bdh1xy49v03lw3g"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-pillow))
+    (propagated-inputs (list python-pillow python-setuptools))
     (inputs (list zbar))
+    (native-inputs (list python-wheel))
     (home-page "https://github.com/Polyconseil/zbarlight")
     (synopsis "Simple Python wrapper for the zbar barcode library")
     (description "Zbarlight is a simple wrapper for the zbar library.  It can
@@ -38183,6 +38283,7 @@ (define-public python-zeroc-ice
                 "0bqkrjxp2fbz34x3wxkxji39kxinypzg8q2994sibiay29mpipxb"))))
     (build-system pyproject-build-system)
     (inputs (list openssl))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://zeroc.com")
     (synopsis "RPC framework")
     (description
diff --git a/gnu/packages/qt.scm b/gnu/packages/qt.scm
index cd0b3d6f9d..e02e7fbfc3 100644
--- a/gnu/packages/qt.scm
+++ b/gnu/packages/qt.scm
@@ -4002,9 +4002,9 @@ (define-public python-sip
      (list python-wrapper python-setuptools python-setuptools-scm-next))
     (propagated-inputs
      (list python-tomli
-           python-packaging))
-    ;; no test.
-    (arguments (list #:tests? #f))
+           python-packaging
+           python-setuptools
+           python-wheel))
     (home-page "https://www.riverbankcomputing.com/software/sip/intro")
     (synopsis "Python binding creator for C and C++ libraries")
     (description
diff --git a/gnu/packages/rpc.scm b/gnu/packages/rpc.scm
index 075a740a88..c083074cc7 100644
--- a/gnu/packages/rpc.scm
+++ b/gnu/packages/rpc.scm
@@ -254,7 +254,7 @@ (define-public python-grpcio
     (inputs
      (list abseil-cpp-20211102.0 c-ares grpc-for-python-grpcio openssl re2 zlib))
     (native-inputs
-     (list python-cython))
+     (list python-cython python-setuptools python-wheel))
     (propagated-inputs
      (list python-six))
     (home-page "https://grpc.io")
diff --git a/gnu/packages/serialization.scm b/gnu/packages/serialization.scm
index 6a4368d59a..80dee15726 100644
--- a/gnu/packages/serialization.scm
+++ b/gnu/packages/serialization.scm
@@ -746,7 +746,9 @@ (define-public python-msgspec
                          python-mypy
                          python-pytest
                          python-setuptools-scm
-                         python-versioneer))
+                         python-versioneer
+                         python-setuptools
+                         python-wheel))
     (propagated-inputs (list python-pyyaml python-tomli python-tomli-w))
     (home-page "https://jcristharif.com/msgspec/")
     (synopsis "Fast serialization/validation library")
diff --git a/gnu/packages/sphinx.scm b/gnu/packages/sphinx.scm
index 472d67c016..aee7ff3809 100644
--- a/gnu/packages/sphinx.scm
+++ b/gnu/packages/sphinx.scm
@@ -453,7 +453,9 @@ (define-public python-sphinx-panels
     (propagated-inputs (list python-docutils-0.15 python-sphinx-4))
     (native-inputs
      (list python-pytest
-           python-pytest-regressions))
+           python-pytest-regressions
+           python-setuptools
+           python-wheel))
     (home-page "https://github.com/executablebooks/sphinx-panels")
     (synopsis "Sphinx extension for creating panels in a grid layout")
     (description
diff --git a/gnu/packages/statistics.scm b/gnu/packages/statistics.scm
index c2bcc776a6..1c1164b432 100644
--- a/gnu/packages/statistics.scm
+++ b/gnu/packages/statistics.scm
@@ -2191,7 +2191,7 @@ (define-public python-vega-datasets
                  ;; Remove dataset with unclear license.
                  (lambda _
                    (delete-file "vega_datasets/_data/la-riots.csv"))))))
-    (native-inputs (list python-pytest))
+    (native-inputs (list python-pytest python-setuptools python-wheel))
     (propagated-inputs (list python-pandas))
     (home-page "https://github.com/altair-viz/vega_datasets")
     (synopsis "Example datasets used by Vega-related projects")
@@ -2236,6 +2236,7 @@ (define-public python-altair
                              python-jsonschema
                              python-numpy
                              python-pandas
+                             python-setuptools
                              python-toolz
                              python-typing-extensions))
     (native-inputs (list python-black
@@ -2323,7 +2324,8 @@ (define-public python-hdmedians
            (lambda _
              ;; Cython extensions have to be built before running the tests.
              (invoke "python" "setup.py" "build_ext" "--inplace"))))))
-    (propagated-inputs (list python-cython python-numpy))
+    (propagated-inputs (list python-cython python-numpy python-setuptools
+                             python-wheel))
     (native-inputs (list python-nose))
     (home-page "http://github.com/daleroberts/hdmedians")
     (synopsis "High-dimensional medians")
@@ -2374,7 +2376,9 @@ (define-public python-arviz
                              python-scipy
                              python-typing-extensions
                              python-xarray
-                             python-xarray-einstats))
+                             python-xarray-einstats
+                             python-setuptools
+                             python-wheel))
     (home-page "https://github.com/arviz-devs/arviz")
     (synopsis "Exploratory analysis of Bayesian models")
     (description
@@ -2670,7 +2674,9 @@ (define-public python-statsmodels
            python-pytest
            python-pytest-randomly
            python-pytest-xdist
-           python-setuptools-scm))
+           python-setuptools-scm
+           python-setuptools
+           python-wheel))
     (home-page
      (string-append "https://www.statsmodels.org/v" version "/"))
     (synopsis "Statistical modeling and econometrics in Python")
diff --git a/gnu/packages/terminals.scm b/gnu/packages/terminals.scm
index 6fb2684326..60ea8e993e 100644
--- a/gnu/packages/terminals.scm
+++ b/gnu/packages/terminals.scm
@@ -115,6 +115,7 @@ (define-module (gnu packages terminals)
   #:use-module (gnu packages popt)
   #:use-module (gnu packages protobuf)
   #:use-module (gnu packages python)
+  #:use-module (gnu packages python-build)
   #:use-module (gnu packages python-check)
   #:use-module (gnu packages python-xyz)
   #:use-module (gnu packages qt)
@@ -255,8 +256,8 @@ (define-public asciinema
                    (substitute* "tests/pty_test.py"
                      (("python3") (search-input-file inputs "/bin/python3"))))))))
     (native-inputs
-     ;; For tests.
-     (list python-pytest))
+     (list python-pytest ; For tests.
+           python-setuptools python-wheel))
     (home-page "https://asciinema.org")
     (synopsis "Terminal session recorder")
     (description
diff --git a/gnu/packages/time.scm b/gnu/packages/time.scm
index dce37f3df4..cb89d04bf5 100644
--- a/gnu/packages/time.scm
+++ b/gnu/packages/time.scm
@@ -285,6 +285,7 @@ (define-public python-dateutils
                 "1wg3f3imjq3snvjccv64h5498pqv9xz664xhni7bsh8mnay91p83"))))
     (build-system pyproject-build-system)
     (propagated-inputs (list python-dateutil python-pytz))
+    (native-inputs (list python-setuptools python-wheel))
     (home-page "https://github.com/jmcantrell/python-dateutils")
     (synopsis "Various utilities for working with date and datetime objects")
     (description
@@ -368,7 +369,7 @@ (define-public python-timezonefinder
       ;; It's optional, remove this constrain where python-pytz is updated.
       #:test-flags #~(list "-k" "not test_with_pytz")))
     (native-inputs
-     (list python-poetry-core python-pytest))
+     (list python-poetry-core python-pytest python-setuptools))
     (propagated-inputs
      (list python-cffi python-h3-3 python-numba python-numpy python-pytz))
     (home-page "https://timezonefinder.michelfe.it/gui")
diff --git a/gnu/packages/tor.scm b/gnu/packages/tor.scm
index 5de1146ce5..421f6733f8 100644
--- a/gnu/packages/tor.scm
+++ b/gnu/packages/tor.scm
@@ -50,6 +50,7 @@ (define-module (gnu packages tor)
   #:use-module (gnu packages glib)
   #:use-module (gnu packages pkg-config)
   #:use-module (gnu packages python)
+  #:use-module (gnu packages python-build)
   #:use-module (gnu packages python-check)
   #:use-module (gnu packages python-crypto)
   #:use-module (gnu packages python-web)
@@ -447,7 +448,8 @@ (define-public tractor
          "1542g6alycwlmvndxcijzn4d5lgycmxxb78gqd8qwgm9kw0fnr3q"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list (list glib "bin")))       ; for glib-compile-schemas.
+     (list python-setuptools python-wheel
+           (list glib "bin")))       ; for glib-compile-schemas.
     (inputs
      (list python-fire
            python-psutil
diff --git a/gnu/packages/tree-sitter.scm b/gnu/packages/tree-sitter.scm
index 2f6e6809d7..8f5bcb8827 100644
--- a/gnu/packages/tree-sitter.scm
+++ b/gnu/packages/tree-sitter.scm
@@ -32,6 +32,7 @@ (define-module (gnu packages tree-sitter)
   #:use-module (gnu packages graphviz)
   #:use-module (gnu packages icu4c)
   #:use-module (gnu packages node)
+  #:use-module (gnu packages python-build)
   #:use-module (guix build-system cargo)
   #:use-module (guix build-system gnu)
   #:use-module (guix build-system pyproject)
@@ -89,7 +90,8 @@ (define-public python-tree-sitter
                     name)))))))))
     (inputs (list tree-sitter))
     (native-inputs
-     (list tree-sitter-python tree-sitter-javascript))
+     (list tree-sitter-python tree-sitter-javascript
+           python-setuptools python-wheel))
     (home-page "https://github.com/tree-sitter/py-tree-sitter")
     (synopsis "Python bindings to the Tree-sitter parsing library")
     (description "This package provides Python bindings to the
diff --git a/gnu/packages/video.scm b/gnu/packages/video.scm
index 20ec379425..000e0ecb44 100644
--- a/gnu/packages/video.scm
+++ b/gnu/packages/video.scm
@@ -6181,7 +6181,7 @@ (define-public gaupol
                 "1z9j3r9pm4rdynlmhgsgnwnnaqw5274yfy4kyillgd77msnpbhaw"))))
     (build-system pyproject-build-system)
     (native-inputs
-     (list gettext-minimal pkg-config))
+     (list gettext-minimal pkg-config python-setuptools python-wheel))
     (inputs
      (list bash-minimal
            python-pygobject
diff --git a/gnu/packages/vim.scm b/gnu/packages/vim.scm
index 6deebdaf2e..e77578cf18 100644
--- a/gnu/packages/vim.scm
+++ b/gnu/packages/vim.scm
@@ -72,6 +72,7 @@ (define-module (gnu packages vim)
   #:use-module (gnu packages perl)
   #:use-module (gnu packages pkg-config)
   #:use-module (gnu packages python)
+  #:use-module (gnu packages python-build)
   #:use-module (gnu packages python-xyz)
   #:use-module (gnu packages ruby)
   #:use-module (gnu packages serialization)
@@ -1030,7 +1031,12 @@ (define-public python-neovim-remote
                (base32
                 "00kxlb3f1k7iaxzpsr07scavmnyg8c1jmicmr13mfk2lcdac6g2b"))))
     (build-system pyproject-build-system)
-    (propagated-inputs (list python-psutil python-pynvim))
+    (native-inputs
+     (list python-wheel))
+    (propagated-inputs
+     (list python-psutil
+           python-pynvim
+           python-setuptools))
     (home-page "https://github.com/mhinz/neovim-remote")
     (synopsis "Control nvim processes using `nvr` commandline tool")
     (description "This package provide a `nvr` command, which can open File in
diff --git a/guix/build-system/pyproject.scm b/guix/build-system/pyproject.scm
index 9a27ebee35..28fd897494 100644
--- a/guix/build-system/pyproject.scm
+++ b/guix/build-system/pyproject.scm
@@ -52,7 +52,12 @@ (define (default-python)
   "Return the default Python package."
   ;; Lazily resolve the binding to avoid a circular dependency.
   (let ((python (resolve-interface '(gnu packages python))))
-    (module-ref python 'python-toolchain)))
+    ;; We are using python-sans-pip-wrapper, because it does not contain
+    ;; setuptools. This allows us to skip the dependency on setuptools for
+    ;; packages which don’t need it. And it allows us to more easily swap
+    ;; out setuptools if a different version is required.
+    ;; Using python-toolchain here might cause dependency cycles.
+    (module-ref python 'python-sans-pip-wrapper)))
 
 (define sanity-check.py
   (search-auxiliary-file "python/sanity-check.py"))