diff --git a/gnu/local.mk b/gnu/local.mk
index eb6f622349..ee4567c857 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1728,7 +1728,6 @@ dist_patch_DATA =						\
   %D%/packages/patches/python-pypdf-annotate-tests-appropriately.patch	\
   %D%/packages/patches/python-sip-include-dirs.patch	\
   %D%/packages/patches/python-sgmllib3k-assertions.patch	\
-  %D%/packages/patches/python-shiboken-2-compat.patch		\
   %D%/packages/patches/python-telingo-fix-comparison.patch	\
   %D%/packages/patches/python-typeguard-python3.10.patch	\
   %D%/packages/patches/python-w3lib-fix-test-failure.patch	\
diff --git a/gnu/packages/patches/python-shiboken-2-compat.patch b/gnu/packages/patches/python-shiboken-2-compat.patch
deleted file mode 100644
index 48aa74173b..0000000000
--- a/gnu/packages/patches/python-shiboken-2-compat.patch
+++ /dev/null
@@ -1,15 +0,0 @@
-Backport a fix from 5.15.9, mentioned in [1].
-
-[1] https://bugreports.qt.io/browse/PYSIDE-2176
-
---- pyside-setup-opensource-src-5.15.8/sources/shiboken2/libshiboken/pep384impl.cpp	2023-04-24 11:05:48.770934499 +0200
-+++ pyside-setup-opensource-src-5.15.8/sources/shiboken2/libshiboken/pep384impl.cpp	2023-04-24 11:04:51.566943936 +0200
-@@ -751,7 +751,7 @@
- #endif // IS_PY2
-     Shiboken::AutoDecRef privateobj(PyObject_GetAttr(
-         reinterpret_cast<PyObject *>(Py_TYPE(self)), Shiboken::PyMagicName::name()));
--#ifndef Py_LIMITED_API
-+#ifdef IS_PY2
-     return _Py_Mangle(privateobj, name);
- #else
-     // PYSIDE-1436: _Py_Mangle is no longer exposed; implement it always.
diff --git a/gnu/packages/qt.scm b/gnu/packages/qt.scm
index 811b42fef5..be882f964c 100644
--- a/gnu/packages/qt.scm
+++ b/gnu/packages/qt.scm
@@ -4179,17 +4179,15 @@ color-related widgets.")
 (define-public python-shiboken-2
   (package
     (name "python-shiboken-2")
-    (version "5.15.8")
+    (version "5.15.10")
     (source (origin
               (method url-fetch)
-              (uri (string-append "https://download.qt.io/official_releases"
-                                  "/QtForPython/pyside2/PySide2-" version
-                                  "-src/pyside-setup-opensource-src-"
+              (uri (string-append "mirror://qt/QtForPython/pyside2/PySide2-"
+                                  version "-src/pyside-setup-opensource-src-"
                                   version ".tar.xz"))
               (sha256
                (base32
-                "0pbbdypwkn3vrgy8ww207fl8pqq4jv80bck9qz5v9dfyr0166hr3"))
-              (patches (search-patches "python-shiboken-2-compat.patch"))))
+                "0fnkx8ax2lkin3bpqbz4zbdrdin2ixb4d6s3c0xghh9sc79r3xia"))))
     (build-system cmake-build-system)
     (inputs
      (list clang-toolchain